83548-46-3 Usage
Description
METHYL N-BOC-L-PROLINE-4-ENE, also known as N-Boc-L-proline-4-ene Methyl Ester, is a L-proline derivative characterized by the presence of a methyl ester group and a protected α-amino group with a tert-butyloxycarbonyl (Boc) group. METHYL N-BOC-L-PROLINE-4-ENE is a key intermediate in the synthesis of various biologically active peptides and peptidomimetics.
Used in Pharmaceutical Industry:
METHYL N-BOC-L-PROLINE-4-ENE is used as a key intermediate for the preparation of dipeptidyl peptidase (DPP) IV inhibitors. DPP-IV inhibitors are a class of drugs that have potential therapeutic applications in the treatment of type 2 diabetes, obesity, and other metabolic disorders. METHYL N-BOC-L-PROLINE-4-ENE plays a crucial role in the synthesis of these inhibitors, contributing to the development of new and effective treatments for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 83548-46-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,5,4 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83548-46:
(7*8)+(6*3)+(5*5)+(4*4)+(3*8)+(2*4)+(1*6)=153
153 % 10 = 3
So 83548-46-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H17NO4/c1-11(2,3)16-10(14)12-7-5-6-8(12)9(13)15-4/h5,7-8H,6H2,1-4H3
83548-46-3Relevant articles and documents
METHOD FOR PRODUCING FLUORINATED PROLINE DERIVATIVE
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Page/Page column 36-38, (2008/06/13)
Disclosed is a method for efficiently producing a high-purity fluorinated proline derivative with high yield. Specifically disclosed is a method for producing a compound represented by the general formula (2) below wherein a compound represented by the formula (1) below is reacted with a fluorination agent, and then chlorine, bromine, iodine, hypochlorous acid, hypochlorite, hypobromous acid, hypobromite or N-halogenosuccinimide is caused to act on the reaction product obtained by the preceding reaction and containing the compound represented by the general formula (2) below and a by-product for chemically changing the by-product. (1) (In the formula (1), R1 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; R2 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; and R3 represents a hydroxyl group or the like.) (2) (In the formula (2), R1 and R2 are as defined above.)
Direktes Verfahren zur Synthese von N-Boc-L-3,4-Didehydroprolin
Dormoy, Jean-Robert,Castro, Bertrand,Chappuis, Georges,Fritschi, Ulrich-Stefan,Grogg, Peter
, p. 761 (2007/10/02)
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