835624-45-8Relevant articles and documents
Asymmetric reduction of perfluoroalkyl ketones with chiral lithium alkoxides
Sokeirik, Yasser Samir,Sato, Kazuyuki,Omote, Masaaki,Ando, Akira,Kumadaki, Itsumaro
, p. 2821 - 2824 (2007/10/03)
Reduction of perfluoroalkyl ketones with chiral lithium alkoxides gave chiral α-perfluoroalkyl alcohols in high enantiomeric excesses. Interestingly, reaction of 2,2,2-trifluoroacetophenone (1) with lithium (S)-1-phenylethoxide (2) gave (S)-2,2,2-trifluoro-1-phenylethanol (3), while the same reaction of perfluorooctan-1-one (7) with 2 gave (R)-1H-1- phenylperfluorooctanol (8). Based on the speculation of mechanism, the order of steric effects on this reaction is estimated as C7F15 > substituted phenyl > CF3.
Synthesis of new axially dissymmetric ligand with large perfluoroalkyl groups
Omote, Masaaki,Nishimura, Yuji,Sato, Kazuyuki,Ando, Akira,Kumadaki, Itsumaro
, p. 319 - 322 (2007/10/03)
A new axially dissymmetric ligand with large perfluoroalkyl groups, 2,2′-bis(1-hydroxy-1H-perfluorooctyl)biphenyl (1c), which could not be obtained by the coupling reaction of the aryl bromide using copper powder, was synthesized successfully by the coupl