837-83-2

Basic information

• Product Name: H-GLY-PRO-ALA-OH
• Synonyms: N-(1-glycyl-L-prolyl)-alanine;Collagenase-Substrate Test Substance (for quantitative Collagenase-Determination);Gly-L-Pro-L-Ala-OH;Gly-Pro-Ala-OH;Gly-Pro-L-Ala-OH;Glycylprolylalanine;NSC 97941;GLY-PRO-ALA
• CAS NO: 837-83-2
• Molecular Formula: C₁₀H₁₇N₃O₄
• Molecular Weight: 243.26
• EINECS: 212-654-6
• Mol File: 837-83-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 579.1 °C at 760 mmHg
• Flash Point: 304 °C
• Appearance: White/Powder
• Density: 1.330
• Vapor Pressure: 6.46E-15mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: −20°C
• Solubility: Methanol (Slightly, Heated), Water (Slightly, Sonicated)
• Stability: Hygroscopic
• BRN: 5288874
• CAS DataBase Reference: H-GLY-PRO-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLY-PRO-ALA-OH(837-83-2)
• EPA Substance Registry System: H-GLY-PRO-ALA-OH(837-83-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 837-83-2(Hazardous Substances Data)

Usage

Description

H-GLY-PRO-ALA-OH, also known as Glycerol, is a simple polyol compound consisting of a hydroxyl group attached to a three-carbon chain. It is a colorless, odorless, and viscous liquid that is hygroscopic in nature. Glycerol is widely used in various industries due to its diverse properties, including its ability to act as a humectant, solvent, and sweetening agent.

Uses

Used in Pharmaceutical Industry:
H-GLY-PRO-ALA-OH is used as an active ingredient in the preparation of preventive and improvement medicine for gingivitis. It helps in maintaining oral hygiene and preventing the onset of gum diseases by reducing inflammation and promoting healing of the gums.
Used in Cosmetics and Personal Care Industry:
Glycerol is used as a humectant in various cosmetic and personal care products, such as skincare creams, lotions, and toothpaste. Its hygroscopic nature helps to retain moisture in the skin, keeping it soft and hydrated.
Used in Food and Beverage Industry:
H-GLY-PRO-ALA-OH is used as a sweetening agent, emulsifier, and preservative in the food and beverage industry. It helps to improve the texture, taste, and shelf life of various food products, such as baked goods, confectionery, and beverages.
Used in Pharmaceutical Industry (cont.):
Glycerol is also used as a solvent in the pharmaceutical industry for the preparation of various medications, such as elixirs, syrups, and liquid dosage forms. Its ability to dissolve a wide range of substances makes it an ideal solvent for drug formulations.
Used in Industrial Applications:
H-GLY-PRO-ALA-OH is used as a raw material in the production of various industrial products, such as antifreeze, de-icing fluids, and explosives. Its unique properties, such as its ability to lower the freezing point of water and its compatibility with other chemicals, make it suitable for these applications.

InChI:InChI=1/C10H17N3O4/c1-6(10(16)17)12-9(15)7-3-2-4-13(7)8(14)5-11/h6-7H,2-5,11H2,1H3,(H,12,15)(H,16,17)

Synthetic route

L-alanin (56-41-7) + H-Gly-Pro-pNA (60189-43-7) → 4-nitro-aniline (100-01-6) + gly-pro-ala (837-83-2) + H-Gly-Pro-OH (704-15-4)

Conditions	Yield
With dipeptidyl peptidase IV In glycerol at 40℃;
With dipeptidyl peptidase IV In glycerol at 40℃; Rate constant; Kinetics; constant of partition;

gly-pro-ala (837-83-2) → L-alanin (56-41-7) + H-Gly-Pro-OH (704-15-4)

Conditions	Yield
at 37℃; for 0.166667h; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR;
at 37℃; for 0.166667h; Rate constant; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR; Km;

Upstream product

• 56-41-7 L-alanin 
• 60189-43-7 H-Gly-Pro-pNA 

Downstream Products

• 56-41-7 L-alanin 
• 704-15-4 H-Gly-Pro-OH 

Relevant articles and documents

Application of the dipeptidyl peptidase IV in formation of the peptide bond

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