83707-15-7 Usage
Description
MANT-CGMP SODIUM SALT, also known as 2''-O-(N''-Methylanthraniloyl)guanosine-3'',5''-cyclic Monophosphate, is a synthetic compound that serves as a substrate for phosphodiesterase studies. It is a modified form of the naturally occurring second messenger molecule, cyclic guanosine monophosphate (cGMP), with a fluorescent anthraniloyl group attached to the 2'' position of the ribose sugar. This modification allows for the detection and analysis of cGMP levels in biological systems, making it a valuable tool in research and drug discovery.
Uses
Used in Pharmaceutical Research:
MANT-CGMP SODIUM SALT is used as a research tool for studying the activity and regulation of phosphodiesterases (PDEs), a family of enzymes that hydrolyze cyclic nucleotides such as cGMP and cyclic adenosine monophosphate (cAMP). By monitoring the fluorescence changes of MANT-CGMP upon its degradation by PDEs, researchers can gain insights into the enzyme's function, inhibition, and potential therapeutic targets.
Used in Drug Discovery:
MANT-CGMP SODIUM SALT is employed as a screening agent in the development of new drugs targeting phosphodiesterases. By assessing the ability of candidate compounds to inhibit or modulate PDE activity, researchers can identify potential therapeutic agents for various diseases and conditions, including cardiovascular disorders, respiratory diseases, and neurological disorders.
Used in Analytical Techniques:
MANT-CGMP SODIUM SALT is utilized in various analytical techniques, such as fluorescence polarization assays and fluorescence resonance energy transfer (FRET) assays, to measure cGMP levels in biological samples. These methods provide a sensitive and quantitative means of detecting changes in cGMP concentrations, which can be useful in studying the effects of drugs, toxins, or other factors on cellular signaling pathways.
Used in Cell Signaling Studies:
MANT-CGMP SODIUM SALT is used as a probe to investigate the role of cGMP in cell signaling pathways. By monitoring the changes in MANT-CGMP fluorescence upon cellular stimulation or treatment with various agents, researchers can gain a better understanding of the mechanisms underlying cGMP-mediated signaling and its implications in cellular function and disease.
Check Digit Verification of cas no
The CAS Registry Mumber 83707-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,7,0 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 83707-15:
(7*8)+(6*3)+(5*7)+(4*0)+(3*7)+(2*1)+(1*5)=137
137 % 10 = 7
So 83707-15-7 is a valid CAS Registry Number.