83820-75-1Relevant articles and documents
Synthesis of ethyl 1,2-dihydro-3H-pyrrolopyrrole-1-carboxylate by an intramolecular carbenoid reaction
Galeazzi, Edvige,Guzman, Angel,Pinedo, Araceli,Saldana, Adolfo,Torre, Diana,Muchowski, Joseph M.
, p. 454 - 456 (2007/10/02)
Cupric ion (or copper) or boron trifluoride promoted decomposition of ethyl 2-diazo-4-(pyrrol-1-yl)butanonate 6 produced mixtures of the title compound 7 and cis and trans ethyl 4-(pyrrol-1-yl)buten-2-oates 9 and 10.The formation of 7 by these processes represents the first reported instances of the intramolecular attack of an α-oxocarbenoid or a Lewis acid complexed α-diazoalkylcarboalkoxy function on the pyrrole nucleus.
5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo?1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
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, (2008/06/13)
Novel 5-(2-pyrroyl) and 5-(N-lower alkyl-2-pyrroyl)-1,2-dihydro-3H-pyrrolo?1,2-a!pyrrole-1-carboxylic acid compounds represented by the formula: STR1 and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein each of R and R1 is independently hydrogen or a lower alkyl group having from 1 to 4 carbon atoms and process for the production of such compounds; 5-(N-methyl-2-pyrroyl)-1,2-dihydro-3H-pyrrolo?1,2-a!pyrrole-1-carboxylic acid is representative of the class. These compounds are useful as anti-inflammatory analgesic and anti-pyretic agents and as smooth muscle relaxants.