84165-81-1

Basic information

• Product Name: 1,3-diethyl 2-(((3-hydroxyphenyl)amino)methylidene)propanedioate
• Synonyms: 1,3-diethyl 2-(((3-hydroxyphenyl)amino)methylidene)propanedioate
• CAS NO: 84165-81-1
• Molecular Weight: 279.293
• Mol File: 84165-81-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3-diethyl 2-(((3-hydroxyphenyl)amino)methylidene)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diethyl 2-(((3-hydroxyphenyl)amino)methylidene)propanedioate(84165-81-1)
• EPA Substance Registry System: 1,3-diethyl 2-(((3-hydroxyphenyl)amino)methylidene)propanedioate(84165-81-1)

Safety Data

• Hazardous Substances Data: 84165-81-1(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 591-27-5 m-Hydroxyaniline 
• 1467782-93-9 diethyl 2-(((3-((4-methoxybenzyl)oxy)phenyl)amino)methylene)malonate 

Downstream Products

• 1467782-93-9 diethyl 2-(((3-((4-methoxybenzyl)oxy)phenyl)amino)methylene)malonate 
• 1373767-16-8 ethyl 7-hydroxy-4-oxo-2-(3-phenoxyphenyl)-1,4-dihydroquinoline-3-carboxylate 
• 1373767-15-7 ethyl 2-([1,1'-biphenyl]-3-yl)-7-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 104047-30-5 C₁₂H₁₁NO₄ 
• 79364-24-2 ethyl 4,5-dihydroxyquinoline-3-carboxylate 
• 64-17-5 ethanol 
• 84490-00-6 3-carbethoxy-4-hydroxy-7-<2'-methyleneoxy-(3'-chloro-4'-p-anisidino-6'-methoxy)quinolyl>quinoline 
• 84489-99-6 2-({3-[3-Chloro-6-methoxy-4-(4-methoxy-phenylamino)-quinolin-2-ylmethoxy]-phenylamino}-methylene)-malonic acid diethyl ester 
• 84489-98-5 2-(m-aminophenoxy)methyl-4-anisidino-3-chloro-6-methoxyquinoline 

Relevant articles and documents

Facile and selective deprotection of PMB ethers and esters using oxalyl chloride

Oxalyl chloride, (0.5 equiv) was found to cleave the PMB group from alkyl, aryl PMB ethers, and esters to give corresponding alcohol and acid in good yields. This method offers simple and efficient protocol for the selective deprotection of PMB ether and ester in DCE at ambient temperature.

Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials

Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization.

An improved synthesis of certain 3-ethoxycarbonylcoumarins

-