842135-93-7

Basic information

• Product Name: Piperazine, 2-[[(4-chlorophenyl)methoxy]methyl]-4-(5-isoquinolinylsulfonyl)-1-(phenyl methyl)-
• CAS NO: 842135-93-7
• Molecular Formula: C28H28ClN3O3S
• Molecular Weight: 522.068
• Mol File: 842135-93-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Piperazine, 2-[[(4-chlorophenyl)methoxy]methyl]-4-(5-isoquinolinylsulfonyl)-1-(phenyl methyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2-[[(4-chlorophenyl)methoxy]methyl]-4-(5-isoquinolinylsulfonyl)-1-(phenyl methyl)-(842135-93-7)
• EPA Substance Registry System: Piperazine, 2-[[(4-chlorophenyl)methoxy]methyl]-4-(5-isoquinolinylsulfonyl)-1-(phenyl methyl)-(842135-93-7)

Safety Data

• Hazardous Substances Data: 842135-93-7(Hazardous Substances Data)

Upstream product

• 134749-45-4 ethyl 1-benzylpiperazine-2-carboxylate 
• 84468-15-5 5-isoquinolinesulfonyl chloride 
• 842135-90-4 1-benzyl-4-(isoquinoline-5-sulfonyl)piperazine-2-carboxylic acid ethyl ester 
• 842135-92-6 [1-benzyl-4-(isoquinoline-5-sulfonyl)piperazin-2-yl]-methanol 
• 622-95-7 4-chlorobenzyl bromide 

Relevant articles and documents

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Structure-based drug design of novel isoquinoline-5-sulfonamide inhibitors of PKB as potential antitumour agents was investigated. Constrained pyrrolidine analogues that mimicked the bound conformation of linear prototypes were identified and investigated by co-crystal structure determinations with the related protein PKA. Detailed variation in the binding modes between inhibitors with similar overall conformations was observed. Potent PKB inhibitors from this series inhibited GSK3β phosphorylation in cellular assays, consistent with inhibition of PKB kinase activity in cells.