84285-38-1Relevant articles and documents
Salvadori,P. et al.
, p. 786 - 787 (1977)
Configurational Prevalence at the Nitrogen Atom in Chiral, Open Chain, Secondary Amines
Salvadori, Piero,Rosini, Carlo,Lazzaroni, Raffaello,Pini, Dario
, p. 1919 - 1922 (2007/10/02)
The stereochemistry of chiral, open chain, secondary amines has been studied by means of low-temperature (1)H and (13)C n.m.r. spectroscopy and by PCILO molecular-orbital calculations.The chiral nitrogen assumes a strongly prevalent configuration under the assymmetric induction of a vicinal asymmetric carbon atom.In the most probable conformation of the secondary amine the lone pair of the nitrogen is placed in the most crowded position.