84339-06-0

Basic information

• Product Name: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester
• Synonyms: Ethyl6,7-difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylate
• CAS NO: 84339-06-0
• Molecular Formula: C₁₂H₉F₂NO₃S
• Molecular Weight: 285.27
• Mol File: 84339-06-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester(84339-06-0)
• EPA Substance Registry System: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester(84339-06-0)

Safety Data

• Hazardous Substances Data: 84339-06-0(Hazardous Substances Data)

Upstream product

• 87238-78-6 ethyl 6,7-difluoro-4-hydroxy-2-(p-methoxybenzylthio)quinoline-3-carboxylate 
• 113028-77-6 ethyl 6,7-difluoro-4-hydroxy-2-<(methoxymethyl)thio>-quinoline-3-carboxylate 
• 155106-44-8 ethyl 3-(4,5-difluoro-2-{[(methylthio)carbonothioyl]amino}phenyl)-3-oxopropanoate 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 155106-46-0 6,7-difluoro-2-(methylthio)-4H-3,1-benzothiazin-4-one 
• 155106-45-9 4,5-Difluoro-2-methylsulfanylthiocarbonylamino-benzoic acid 
• 113028-75-4 3,4-difluorophenyl isothiocyanate 
• 144514-15-8 3,4-difluorophenyl dithiocarbamic acid triethylammonium 
• 113028-76-5 diethyl<<(3,4-difluorophenyl)amino><(methoxymethyl)-thio>methylene>malonate 
• 3863-11-4 3,4-difluoroaniline 
• 150454-50-5 diethyl 3,4-difluorophenylamino(p-methoxybenzylthio)methylenemalonate 
• 150454-48-1 sodium salt of diethyl 3,4-difluorophenylamino(mercapto)methylenemalonate 

Downstream Products

• 113046-72-3 ethyl 6,7-difluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 
• 144514-21-6 6,7-Difluoro-4-oxo-1-phenyl-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 144514-22-7 6,7-Difluoro-1-(4-fluoro-phenyl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 144514-23-8 6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 144514-24-9 1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 258879-74-2 ethyl 6,7-difluoro-2-(2-fluoroethyl)thio-4-[(2R)-2-phenylpropionyl]oxyquinoline-3-carboxylate 
• 175074-18-7 ethyl 2-(1-chloro-2-fluoroethyl)thio-6,7-difluoro-4-[(2R)-2-phenylpropionyl]oxyquinoline-3-carboxylate 
• 112984-60-8 ulifloxacin 
• 113028-17-4 ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113046-49-4 6-Fluoro-4-oxo-1-phenyl-7-(1-piperazinyl)-4H-[1,3]-thiazeto-[3,2-a]quinoline-3-carboxylic acid 
• 113045-95-7 ethyl 6-fluoro-4-oxo-1-phenyl-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113045-94-6 ethyl 6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1-phenyl-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113046-68-7 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 113028-65-2 6-Fluoro-1-(2-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and antibacterial activity of novel 7-substituted-6-fluoro-1- fluoromethyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives

A series of 7-substituted-6-fluoro-1-fluoromethyl-4-oxo-4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives (2a - I) was prepared and evaluated for antibacterial activity. These compounds were obtained by deacylation of 4-benzoyloxy-2-(1-chloro-2-fluoroethyl)thio-6,7- difluoroquinoline-3-carboxylate (10) and subsequent intramolecular cyclization followed by substitution with cyclic amines and then hydrolysis. The intramolecular cyclization reaction of 18, one of the diastereomers (17, 18) revealed that the cyclization reaction proceeded through an inversion to afford (-)-11a in good chemical and optical yield. The enantiomers of 2a were prepared from the enantiomers of 11a, which were obtained by the optical resolution of the racemate using high-performance liquid chromatography (HPLC). Compounds 2a,b showed excellent in vitro and in vivo antibacterial activity against both gram-negative and gram-positive bacteria including quinolone and Methicillin-resistant Staphylococcus aureus.

STUDIES ON PYRIDONECARBOXYLIC ACIDS. 1. SYNTHESIS AND ANTIBACTERIAL EVALUATION OF 7-SUBSTITUTED-6-HALO-4-OXO-4H-THIAZETOQUINOLINE-3-CARBOXYLIC ACIDS

A series of thiazetoquinoline-3-carboxylic acids and their esters were prepared and evaluated for antibacterial activity.The derivatives with a hydrogen or methyl group at C-1, fluorine at C-6, and piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity.Compound 29a (NM394) showed excellent in vitro antibacterial activity and low toxicity but poor absorption from the gastrointestinal tract.Compound 29ee (NM441), an N- derivative of 29a, was found to possess a favorable pharmacokinetic profile and oral activity superior to that of ciprofloxacin in experimental animals.

Studies on pyridonecarboxylic acids. 2. Synthesis and antibacterial activity of 8-substituted-7-fluoro-5-oxo-5H-thiazolo[3,2-a]quinoline-4-carboxylic acids

-