845-05-6

Basic information

• Product Name: 4'-methoxy-3-(trifluoromethyl)benzophenone
• Synonyms: 4'-methoxy-3-(trifluoromethyl)benzophenone;4-Methoxyphenyl[3-(trifluoromethyl)phenyl]methanone
• CAS NO: 845-05-6
• Molecular Formula: C₁₅H₁₁F₃O₂
• Molecular Weight: 280.2418496
• EINECS: 212-681-3
• Mol File: 845-05-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-methoxy-3-(trifluoromethyl)benzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-methoxy-3-(trifluoromethyl)benzophenone(845-05-6)
• EPA Substance Registry System: 4'-methoxy-3-(trifluoromethyl)benzophenone(845-05-6)

Safety Data

• Hazardous Substances Data: 845-05-6(Hazardous Substances Data)

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 536-45-8 sodium anisate 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 100-66-3 methoxybenzene 
• 454-92-2 3-(trifluoromethyl)benzoic acid 

Downstream Products

• 732-55-8 (4-hydroxyphenyl)(3-(trifluoromethyl)phenyl)methanone 
• 66938-44-1 (4-Methoxy-3-nitro-phenyl)-(3-trifluoromethyl-phenyl)-methanone 
• 65214-64-4 4'-Methoxy-3-trifluormethyl-benzhydrol 
• 2560-61-4 4',4''-Dimethoxy-3,3'-bis-trifluormethyl-benzpinakon 
• 6615-92-5 1-Methoxyphenyl-2-phenyl-1-(3-trifluormethyl-phenyl)-aethylen 
• 66938-64-5 (4-Amino-3-nitro-phenyl)-(3-trifluoromethyl-phenyl)-methanone 
• 6615-93-6 2-Brom-1-methoxyphenyl-2-phenyl-1-(3-trifluormethyl-phenyl)-aethylen 
• 62519-54-4 3-(4-methoxy-phenyl)-3-(3-trifluoro-methyl-phenyl)-propionic acid ethyl ester 

Relevant articles and documents

Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase

We discovered a new series of 4-phenoxyquinoline derivatives as potent and selective inhibitors of the platelet-derived growth factor receptor (PDGFr) tyrosine kinase. We researched the highly potent and selective inhibitors on the basis of both PDGFr and epidermal growth factor receptor (EGFr) inhibitory activity. First, we found a compound, Ki6783 (1), which inhibited PDGFr autophosphorylation at 0.13 μM, but it did not inhibit EGFr autophosphorylation at 100 μM. After extensive explorations, we found the two desired compounds, Ki6896 (2) and Ki6945 (3), which are substituted by benzoyl and benzamide at the 4-position of the phenoxy group on 4-phenoxyquinoline, respectively. These inhibitory activities were 0.31 and 0.050 μM, respectively, but neither of them inhibited EGFr autophosphorylation at 100 μM. We further investigated the profile of both compounds toward various tyrosine and serine/threonine kinases. The three compounds specifically inhibited PDGFr rather than the other kinases.

Polycyclic compounds

Compounds of the formula (II): STR1 and pharmaceutically acceptable salts thereof, wherein R1 is phenyl or naphthyl or substituted phenyl or naphthyl group; R2 is: STR2 wherein R5 is hydrogen or C1-6 alkyl, R6 is hydrogen or C1-6 alkyl, phenyl, tolyl or benzyl and R7 is hydrogen; R3 and R4 are each hydrogen atom or C1-4 alkyl, and X is CO, CHOH, CHCI or C=C R8 R9 wherein R8 and R9 are each hydrogen or C1-4 alkyl; or CR10 OH or CHR10, wherein R10 is C1-4 alkyl, have been found to be mood-modifying agents and anorexic agents.