845827-13-6

Basic information

• Product Name: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-
• Synonyms: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-;5-Bromo-alpha,alpha-difluoro-2-picoline;3-Bromo-6-(difluoromethyl)pyridine;5-Bromo-2-(difluoromethyl)pyridine 95%
• CAS NO: 845827-13-6
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.005
• EINECS: 200-258-5
• Mol File: 845827-13-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 35-40℃
• Boiling Point: 206.644 °C at 760 mmHg
• Flash Point: 89°(192°F)
• Appearance: White to yellow/Solid
• Density: 1.64
• Storage Temp.: 2-8°C
• PKA: -0.83±0.29(Predicted)
• CAS DataBase Reference: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(845827-13-6)
• EPA Substance Registry System: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(845827-13-6)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 845827-13-6(Hazardous Substances Data)

Usage

General Description

PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- is a chemical compound with the molecular formula C6H3BrF2N. It is a brominated pyridine derivative that contains a difluoromethyl group. PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- is commonly used in organic synthesis and as a building block in pharmaceutical manufacturing. It may also have potential applications in agrochemicals and materials science. It is important to handle this chemical with caution as it may have hazardous properties and should be used in accordance with safety protocols and regulations.

Upstream product

• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 223463-13-6 2-iodo-5-bromopyridine 
• 1438388-96-5 tributyl(difluoromethyl)stannane 
• 294181-95-6 2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester 

Downstream Products

• 845826-93-9 4-[6-(difluoromethyl)-pyridin-3-yl]benzenecarboxylic acid 

Relevant articles and documents

NEW ANTI-MALARIAL AGENTS

The present invention is related to new derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to dihydroisoquinoline derivatives useful for the preparation of a pharmaceutical for

Deoxyfluorination of (Hetero)aryl Aldehydes Using Tetramethylammonium Fluoride and Perfluorobutanesulfonyl Fluoride or Trifluoromethanesulfonic Anhydride

This Communication describes the conversion of (hetero)aryl aldehydes into the corresponding (hetero)aryl difluoromethyl products using anhydrous NMe4F in combination with perfluorobutanesulfonyl fluoride or trifluoromethanesulfonic anhydride.

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.