846057-27-0

Basic information

• Product Name: 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone
• Synonyms: 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone;1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one;1-Acetyl-4-piperidinemethanol
• CAS NO: 846057-27-0
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.2102
• Mol File: 846057-27-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 309.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.067±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone(846057-27-0)
• EPA Substance Registry System: 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone(846057-27-0)

Safety Data

• Hazardous Substances Data: 846057-27-0(Hazardous Substances Data)

Usage

General Description

1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone is a chemical compound with a molecular formula C9H17NO2. It is also known as piperidin-4-yl-methyl-ethanone and is classified as a piperidine derivative. 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone is used in the synthesis of pharmaceuticals, including antiviral and antifungal agents. It is also used as an intermediate in the production of other organic compounds. 1-(4-HydroxyMethyl-piperidin-1-yl)-ethanone has a wide range of potential applications in the pharmaceutical and chemical industries due to its versatile properties and chemical structure.

Upstream product

• 2494-10-2 1-piperidinomethanol 
• 6457-49-4 4-piperidinemethanol 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 90748-01-9 4-piperidinemethanol hydrochloride 

Downstream Products

• 846057-25-8 (1-acetylpiperidin-4-yl)methyl 4-methylbenzenesulfonate 

Relevant articles and documents

HETEROCYCLIC COMPOUND INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Disclosed by the invention is a heterocyclic compound, an intermediate, and a preparation method therefor and an application thereof. Provided by the invention are a heterocyclic compound as shown in formula I, and a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, an ester, a pharmaceutically acceptable salt or a prodrug thereof. The heterocyclic compound hasa high P2X3 antagonistic activity, and has good selectivity, low toxicity, good metabolic stability and little taste influence.

N-ACYL-{4-[(4-ARYL-PHENYL)SULFONYLMETHYL]PIPERIDINE} COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain N-acyl-{4-[(4-aryl- phenyl)sulfonylmethyl]piperidine} compounds of the following formula (collectively referred to

Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent

A series of novel benzamide derivatives, altering the 4-fluorophenylalkyl moiety in cisapride, were synthesized as 5-HT4 receptor agonists, and SAR of these analogs was examined on in vitro and in vivo prokinetic activities. These compounds were synthesized for high 5-HT4 receptor binding affinities and low hERG affinities. Several types of analogs were obtained and screened for 5-HT4 binding, hERG blocking, agonism, and gastric emptying assessment. Among the analogues, compound 23g showed promising results compared with the other analogs with respect to gastric emptying rates in rats. Therefore, we suggest that it may be a clinical candidate for the development of a potent prokinetic agent to treat GI disorders.