84680-54-6 Usage
Description
ENALAPRILAT DIHYDRATE is the active metabolite of enalapril, a nonsulfhydryl dipeptide angiotensin-converting enzyme (ACE) inhibitor. It plays a crucial role in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies by inhibiting the conversion of angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange.
Uses
Used in Pharmaceutical Industry:
ENALAPRILAT DIHYDRATE is used as an active metabolite for the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies. It functions as a nonsulfhydryl dipeptide angiotensin-converting enzyme (ACE) inhibitor, helping to regulate blood pressure and improve cardiovascular health.
Used in Research and Development:
ENALAPRILAT DIHYDRATE is used as an impurity standard in the development and quality control of enalapril-related pharmaceutical products. It helps ensure the purity, potency, and safety of enalapril-based medications, contributing to the overall efficacy and reliability of these treatments.
Biochem/physiol Actions
Enalapril, the ethyl ester of?enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to?enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.
Check Digit Verification of cas no
The CAS Registry Mumber 84680-54-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,6,8 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84680-54:
(7*8)+(6*4)+(5*6)+(4*8)+(3*0)+(2*5)+(1*4)=156
156 % 10 = 6
So 84680-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14+,15+/m0/s1
84680-54-6Relevant articles and documents
Method for the synthesis of amines and amino acids with organoboron derivatives
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, (2008/06/13)
Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.
Prodrug derivatives of carboxylic acid drugs
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, (2008/06/13)
Novel ester derivatives of carboxylic acid medicaments of formula (I), wherein R--COO--represents the acyloxy residue of a carboxylic acid drug or medicament, n is an integrer from 1 to 3, and R1 and R2 are the same or different and are selected from a group consisting of an alkyl, an alkenyl, an aryl, an aralkyl, a cycloalkyl and which group may be unsubstituted or substituted, or R1 and R2 together with the N forms a 4-, 5-, 6- or 7-membered heterocyclic ring, which in addition to the nitrogen atom may contain one or two further heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and which heterocyclic group may be substituted. These compounds are highly biolabile prodrug forms of the corresponding carboxylic acid compounds and are highly susceptible to undergoing enzymatic hydrolysis in vivo whereas they are highly stable in aqueous solution. The novel derivatives are less irritating to mucosa than the parent carboxylic acids and may provide an improved bio-availability of the drugs.
