848188-16-9

Basic information

• Product Name: Pyridine, 2-[2-[5-chloro-2-(phenylmethoxy)phenyl]-3-thienyl]-6-[[[tris(1-methylethyl) silyl]oxy]methyl]-
• CAS NO: 848188-16-9
• Molecular Formula: C32H38ClNO2SSi
• Molecular Weight: 564.264
• Mol File: 848188-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-[2-[5-chloro-2-(phenylmethoxy)phenyl]-3-thienyl]-6-[[[tris(1-methylethyl) silyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-[2-[5-chloro-2-(phenylmethoxy)phenyl]-3-thienyl]-6-[[[tris(1-methylethyl) silyl]oxy]methyl]-(848188-16-9)
• EPA Substance Registry System: Pyridine, 2-[2-[5-chloro-2-(phenylmethoxy)phenyl]-3-thienyl]-6-[[[tris(1-methylethyl) silyl]oxy]methyl]-(848188-16-9)

Safety Data

• Hazardous Substances Data: 848188-16-9(Hazardous Substances Data)

Upstream product

• 21190-88-5 6-bromopyridine-2-carboxylic acid ethyl ester 
• 33674-96-3 2-bromo-6-(hydroxymethyl)pyridine 
• 100-39-0 benzyl bromide 
• 695-96-5 2-bromo-4-chlorophenol 
• 848188-11-4 2-thiophen-3-yl-6-triisopropylsilanyloxymethyl-pyridine 
• 848188-09-0 2-bromo-6-(((triisopropylsilyl)oxy)methyl)pyridine 
• 151038-76-5 1-(benzyloxy)-2-bromo-4-chlorobenzene 

Relevant articles and documents

2,3-Diarylthiophenes as selective EP1 receptor antagonists

The synthesis and the EP1 receptor binding affinity of 2,3-diarylthiophene derivatives are described. The evaluation of the structure-activity relationship (SAR) in this series led to the identification of compounds 4, 7, and 12a, which exhibit high affinity for the human EP 1 receptor and a selectivity greater than 100-fold against the EP2, EP3, EP4, DP, FP, and IP receptors and greater than 25-fold versus the TP receptor. These three antagonists present good pharmacokinetics in rats and significant differences in the way they are distributed in the brain.