848188-31-8Relevant articles and documents
Syntheses and biological activity of amamistatin B and analogs
Fennell, Kelley A.,Moellmann, Ute,Miller, Marvin J.
, p. 1018 - 1024 (2008/09/18)
(Chemical Equation Presented) Amamistatins A and B, natural products isolated from a strain of Nocardia, showed growth inhibition against three human tumor cell lines (IC50 0.24-0.56 μM). Structurally related mycobactins affect the growth of bo
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors
Razavi, Hossein,Powers, Evan T.,Purkey, Hans E.,Adamski-Werner, Sara L.,Chiang, Kyle P.,Dendle, Maria T. A.,Kelly, Jeffery W.
, p. 1075 - 1078 (2007/10/03)
Ten oxazoles bearing a C(4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C(2) position of the oxazole ring reveals that a 3,5-dichlorophenyl substituent significantly reduced amy