848488-91-5

Basic information

• Product Name: (R)-1-N-BOC-PIPECOLAMIDE
• Synonyms: N-Boc-D-2-piperidinecarboxamide;(R)-2-Carbamoyl-piperidine-1-carboxylic acid tert-butyl ester;(R)-1-Boc-2-piperidinecarboxaMide;(R)-tert-butyl 2-carbamoylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-;(R)-tert-Butyl 2-carbamoyllpiperidine-1-carboxylate;(R)-1-Boc-2-(aminocarbonyl)piperidine
• CAS NO: 848488-91-5
• Molecular Formula: C11H20N2O3
• Molecular Weight: 228.29
• Mol File: 848488-91-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 384.4 °C at 760 mmHg
• Flash Point: 186.3 °C
• Appearance: /
• Density: 1.123 g/cm³
• Vapor Pressure: 4.1E-06mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-1-N-BOC-PIPECOLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-N-BOC-PIPECOLAMIDE(848488-91-5)
• EPA Substance Registry System: (R)-1-N-BOC-PIPECOLAMIDE(848488-91-5)

Safety Data

• Hazardous Substances Data: 848488-91-5(Hazardous Substances Data)

Usage

General Description

(R)-1-N-BOC-PIPECOLAMIDE, also known as (R)-1-N-BOC-pipecolic acid amide, is a chemical compound that is commonly used as a building block in the synthesis of various pharmaceuticals and other organic molecules. It is a derivative of pipecolic acid, a naturally occurring cyclic amino acid, which has been found to possess anti-inflammatory and immunomodulatory properties. The BOC (tert-butoxycarbonyl) protecting group in the compound helps to improve its stability and reactivity, making it a useful intermediate for the preparation of diverse chemical structures. (R)-1-N-BOC-PIPECOLAMIDE is often employed in the creation of peptide-based drugs and is considered a valuable tool for organic chemists in the development of new medicinal compounds.

InChI:InChI=1/C11H20N2O3/c1-11(2,3)16-10(15)13-7-5-4-6-8(13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14)/t8-/m1/s1

Upstream product

• 28697-17-8 N-BOC-D-pipecolic acid 

Downstream Products

• 940000-26-0 1,1-dimethylethyl (2R)-2-cyano-1-piperidinecarboxylate 
• 1089729-72-5 (R)-2-thiocarbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1089729-31-6 (R)-2-phenoxy-1-(2-(4-(pyridin-2-yl)thiazol-2-yl)piperidin-1-yl)ethan-1-one 
• 1089729-26-9 1-{(R)-2-[4-(4-Chloro-phenyl)-thiazol-2-yl]-piperidin-1-yl}-2-phenoxy-ethanone 
• 1089729-80-5 (R)-2-[4-(4-chloro-phenyl)-thiazol-2-yl]-piperidinium trifluoroacetate 
• 1089729-74-7 (R)-2-[4-(4-chloro-phenyl)-thiazol-2-yl]-piperidine 
• 111478-74-1 (R)-2-(aminomethyl)piperidine 

Relevant articles and documents

IAP ANTAGONISTS AND THEIR THERAPEUTIC APPLICATIONS

The present invention relates to Formula I. compounds including their isomers, tautomeric forms and rotamers, salts together with their manufacturing process and their pharmacological use alone or in combination with other active ingredients for the treatment of cell and tissue malignances caused diseases, including uncontrolled cell or tissue growth, proliferation and cancer.

Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery of new drugs. Herein, we have identified several classes of small molecules with broad spectrum activity against these pathogens. Previously, we reported the identification of carnitine palmitoyltransferases (CPTs) as a representative class of enzymes as potential targets for metabolic chokepoint intervention that was elucidated from a combination of chemogenomic screening and experimental testing in nematodes. Expanding on these previous findings, we have discovered that several chemical classes of known small molecule inhibitors of mammalian CPTs have potent activity as anthelmintics. Cross-clade efficacy against a broad spectrum of adult parasitic nematodes was demonstrated for multiple compounds from different series. Several analogs of these initial hit compounds were designed and synthesized. The compounds we report represent a good starting point for further lead identification and optimization for development of new anthelmintic drugs with broad spectrum activity and a novel mechanism of action.

POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. Compound (I) wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.