848774-93-6

Basic information

• Product Name: (6-METHYLPYRIDAZIN-3-YL)METHANOL
• Synonyms: (6-METHYLPYRIDAZIN-3-YL)METHANOL
• CAS NO: 848774-93-6
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• Mol File: 848774-93-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (6-METHYLPYRIDAZIN-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (6-METHYLPYRIDAZIN-3-YL)METHANOL(848774-93-6)
• EPA Substance Registry System: (6-METHYLPYRIDAZIN-3-YL)METHANOL(848774-93-6)

Safety Data

• Hazardous Substances Data: 848774-93-6(Hazardous Substances Data)

Usage

General Description

(6-METHYLPYRIDAZIN-3-YL)METHANOL is a chemical compound with the molecular formula C8H10N2O. It is a derivative of pyridazine and contains a methyl group attached to the third carbon atom of the pyridazine ring, as well as a hydroxyl group attached to the carbon atom adjacent to the nitrogen atom in the pyridazine ring. (6-METHYLPYRIDAZIN-3-YL)METHANOL is a colorless liquid with a molecular weight of 150.18 g/mol. It is commonly used as a reagent in organic synthesis and chemical research. Additionally, it may have medicinal or pharmaceutical applications due to its structural similarity to certain biologically active compounds. However, further research is needed to fully understand its potential uses and properties.

Upstream product

• 635324-41-3 6-methylpyridazine-3-carbaldehyde 
• 3857-25-8 2-hydroxymethyl-5-methylfuran 
• 1121-79-5 3-chloro-6-methylpyridazine 
• 848774-92-5 3-methyl-6-vinylpyridazine 
• 64210-57-7 ethyl 6-methylpyridazine-3-carboxylate 

Relevant articles and documents

SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS

Substituted Pyrazolo-pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B receptor activity.

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.