849020-94-6 Usage
Description
TERT-BUTYL2-(AMINOMETHYL)PHENYLCARBAMATE is an organic compound that serves as a versatile reactant in the synthesis of various complex organic molecules. It is characterized by its ability to participate in multiple-step reactions, making it a valuable component in organic chemistry.
Uses
Used in Pharmaceutical Synthesis:
TERT-BUTYL2-(AMINOMETHYL)PHENYLCARBAMATE is used as a reactant for the two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines employing a double UDC (Ugi/Deprotect/Cyclize) strategy. This application is crucial in the development of novel pharmaceutical compounds with potential therapeutic applications.
Used in Organic Chemistry Research:
In the field of organic chemistry, TERT-BUTYL2-(AMINOMETHYL)PHENYLCARBAMATE is utilized as a reactant for the preparation of hydroquinazoline scaffolds via microwave-promoted Ugi reaction and cyclization. This process allows for the efficient synthesis of complex molecular structures, which are essential in various chemical and pharmaceutical research endeavors.
Used in Enzyme Inhibitor Development:
TERT-BUTYL2-(AMINOMETHYL)PHENYLCARBAMATE is also used as a reactant in the preparation of pyrazinone inhibitors of mast cell tryptase. These inhibitors play a significant role in the study and potential treatment of various inflammatory and immune disorders by targeting key enzymes involved in these processes.
Check Digit Verification of cas no
The CAS Registry Mumber 849020-94-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,0,2 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 849020-94:
(8*8)+(7*4)+(6*9)+(5*0)+(4*2)+(3*0)+(2*9)+(1*4)=176
176 % 10 = 6
So 849020-94-6 is a valid CAS Registry Number.
849020-94-6Relevant articles and documents
Concise preparation of novel tricyclic chemotypes: Fused hydantoin-benzodiazepines
Gunawan, Steven,Nichol, Gary S.,Chappeta, Shashi,Dietrich, Justin,Hulme, Christopher
experimental part, p. 4689 - 4692 (2010/09/20)
The following article describes a concise synthesis of a collection of 4,5-dihydro-1H-benzo[e][1,4]diazepines fused to a hydantoin ring. Molecular complexity and biological relevance are high and structures are generated in a mere three steps, employing the Ugi reaction to assemble diversity reagents. The protocol represents a novel UDC (Ugi-deprotect-cyclize) strategy employed in the Ugi-5-component CO2-mediated condensation, followed by further cyclization under basic conditions, to afford the fused hydantoin. Mechanistic caveats, dependent on the aldehydes of choice will be revealed and a facile oxidation of the final products to imidazolidenetriones is briefly discussed.
