849021-44-9 Usage
Description
1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE is a heterocyclic chemical compound that features a 1,4-diazepane ring system with a bromopyrimidine substituent. This unique structure endows it with potential biological activities, making it a valuable compound in medicinal chemistry. Its distinctive properties, particularly due to the bromopyrimidine group, offer a wide range of applications in drug development and chemical biology research.
Uses
Used in Pharmaceutical Industry:
1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE is used as a key intermediate in drug synthesis for the development of new therapeutic agents. Its unique structure allows for the design of molecules with specific biological targets, potentially leading to the creation of novel drugs with improved efficacy and selectivity.
Used in Chemical Biology Research:
In the field of chemical biology, 1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE serves as a valuable research tool. Its heterocyclic nature and the presence of the bromopyrimidine group make it suitable for studying molecular interactions, probing biological pathways, and understanding the mechanisms of action of various biologically active compounds.
Used in Medicinal Chemistry:
1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE is utilized in medicinal chemistry for the design and optimization of drug candidates. Its unique chemical properties can be leveraged to create molecules with enhanced pharmacokinetic and pharmacodynamic profiles, contributing to the advancement of drug discovery and development processes.
Check Digit Verification of cas no
The CAS Registry Mumber 849021-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,0,2 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 849021-44:
(8*8)+(7*4)+(6*9)+(5*0)+(4*2)+(3*1)+(2*4)+(1*4)=169
169 % 10 = 9
So 849021-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H13BrN4/c10-8-6-12-9(13-7-8)14-4-1-2-11-3-5-14/h6-7,11H,1-5H2
849021-44-9Relevant articles and documents
Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni
Bachovchin, Kelly A.,Bag, Seema,Buskes, Melissa J.,Caffrey, Conor R.,Campbell, Robert F.,Clements, Monica,El-Sakkary, Nelly,Ferrins, Lori,Jalani, Hitesh B.,Klug, Dana M.,Leonard, Allison,Pollastri, Michael P.,Sciotti, Richard J.,Singh, Baljinder
supporting information, p. 258 - 265 (2020/03/30)
We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm parasite, Schistosoma mansoni. This study reports the identification and preliminary development of several potently bioactive compounds against adult schistosomes, one or more of which represent promising leads for further assessment and optimization.
