849409-82-1

Basic information

• Product Name: 3-(Propane-1-sulfonaMido)benzoic acid
• Synonyms: 3-(Propane-1-sulfonaMido)benzoic acid;3-(Propane-1-sulfonylamino)-benzoic acid
• CAS NO: 849409-82-1
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.27952
• Mol File: 849409-82-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Propane-1-sulfonaMido)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Propane-1-sulfonaMido)benzoic acid(849409-82-1)
• EPA Substance Registry System: 3-(Propane-1-sulfonaMido)benzoic acid(849409-82-1)

Safety Data

• Hazardous Substances Data: 849409-82-1(Hazardous Substances Data)

Upstream product

• 849409-81-0 3-(propane-1-sulfonylamino)-benzoic acid ethyl ester 
• 618-95-1 methyl 3-nitrobenzoate 
• 4518-10-9 Methyl 3-aminobenzoate 
• 121-92-6 3-nitrobenzoic acid 
• 10147-36-1 n-propanesulfonyl chloride 

Relevant articles and documents

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

The mitogen-activated protein kinase (MAP) kinase 4 (MKK4) was found to be a major regulator of liver regeneration and could be a valuable drug target addressing liver related diseases by restoring its intrinsic regenerative capacity. We report on the synthesis and optimization of novel MKK4 inhibitors following a target-hopping strategy from the FDA-approved BRAFV600E inhibitor PLX4032 (8). Applying an iterative multi-parameter optimization process we carved out essential structural features yielding in compounds with a low nanomolar affinity for MKK4 and excellent selectivity profiles against the main off-targets MKK7 and JNK1, which, upon relevant inhibition, would totally abrogate the pro-regenerative effect of MKK4 inhibition, as well as against the off-targets MAP4K5, ZAK and BRAF with selectivity factors ranging from 40 to 430 for our best-balanced compounds 70 and 73.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein R x, R y , R z and R zz are selected from: a) R x and R y are F and R z and R zz are H; b) R x, R y and R zz are independently halogen and R z is H; c) R x R z and R zz are independently halogen and R y is H; and d) R x R y and R z are independently halogen and R zz is H

NOVEL SULFONE AMIDE DERIVATIVES CAPABLE OF INHIBITING BACE

The present invention relates to novel derivatives of sulfone amide of Formula 1 as defined in this disclosure which inhibit the activity of BACE (or beta-secretase). These sulfone amide derivatives are useful for the treatment and prevention of Alzheimer's disease and related diseases caused by production of beta-amyloid, by inhibiting the activity of BACE.