849519-42-2

Basic information

• Product Name: Pyrrolidine, 1-[2-(4-bromophenyl)ethyl]-2-methyl-, (2R)-
• CAS NO: 849519-42-2
• Molecular Formula: C13H18BrN
• Molecular Weight: 268.197
• Mol File: 849519-42-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[2-(4-bromophenyl)ethyl]-2-methyl-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[2-(4-bromophenyl)ethyl]-2-methyl-, (2R)-(849519-42-2)
• EPA Substance Registry System: Pyrrolidine, 1-[2-(4-bromophenyl)ethyl]-2-methyl-, (2R)-(849519-42-2)

Safety Data

• Hazardous Substances Data: 849519-42-2(Hazardous Substances Data)

Upstream product

• 114369-15-2 2-(4-bromophenyl)ethyl methanesulfonate 
• 765-38-8 (R)-(-)-2-methylpyrrolidine 
• 4654-39-1 4-bromophenethanol 

Downstream Products

• 1048964-43-7 C₂₇H₃₆N₂O 
• 1181690-16-3 (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride 
• 1181690-50-5 (R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1181690-30-1 (R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride 
• 1181690-53-8 (R)-3-methoxy-1-(7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one hydrochloride 
• 1620084-88-9 (R)-2-(2-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)ethyl)-2H-tetrazole 
• 1620084-87-8 (R)-1-(2-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)ethyl)-1H-tetrazole 
• 1021169-88-9 (2R)-2-methyl-1-(2-(4'-((tetrahydro-2H-pyran-2-yl)methylsulfonyl)biphenyl-4-yl)ethyl)pyrrolidine 

Relevant articles and documents

MODULATORS OF THE HISTAMINE H3 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders.

METHODS AND COMPOUNDS USEFUL IN TREATING PRURITUS, AND METHODS FOR IDENTIFYING SUCH COMPOUNDS

The present invention relates to methods of using histamine 3 receptor (H3R) antagonists to treat pruritus or itch in an individual and methods for using H3R to screen for compounds capable of treating pruritus in an individual and methods for using pruritus/itch model systems for screening H3R antagonists for their usefulness in treating pruritus.

Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H3 receptor inverse agonist activity

Antagonism of the histamine-H3 receptor is one tactic being explored to increase wakefulness for the treatment of disorders such as excessive daytime sleepiness (EDS) as well as other sleep or cognitive disorders. Phenethyl-R-2-methylpyrrolidin