849937-91-3 Usage
General Description
4,6-Difluoronicotinic acid is a chemical compound with the molecular formula C6H3F2NO2. It falls in the category of organic compounds, specifically heteroaromatic compounds, which are compounds characterized by their aromatic ring containing one or more atoms other than carbon, typically nitrogen, oxygen, or sulfur. In the case of 4,6-Difluoronicotinic acid, the heteroatom is nitrogen. The chemical is usually used as a pharmaceutical intermediate meaning it's used to produce other drugs. Furthermore, it exhibits properties of both organic and inorganic acids because of the presence of the carboxyl group (-COOH) in its structure.
Check Digit Verification of cas no
The CAS Registry Mumber 849937-91-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,9,3 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 849937-91:
(8*8)+(7*4)+(6*9)+(5*9)+(4*3)+(3*7)+(2*9)+(1*1)=243
243 % 10 = 3
So 849937-91-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H3F2NO2/c7-4-1-5(8)9-2-3(4)6(10)11/h1-2H,(H,10,11)
849937-91-3Relevant articles and documents
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick
Schlosser, Manfred,Bobbio, Carla,Rausis, Thierry
, p. 2494 - 2502 (2007/10/03)
(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.
