85118-02-1

Basic information

• Product Name: 2,4-DIFLUOROBENZAMIDE
• Synonyms: 2,4-DIFLUOROBENZAMIDE;DIFLUORO BENZAMIDE;Benzamide, 2,4-difluoro-;2,4-Difluorobenzamide 99%;2,4-Difluorobenzamide99%;2,4-fluorobenzamide
• CAS NO: 85118-02-1
• Molecular Formula: C₇H₅F₂NO
• Molecular Weight: 157.12
• EINECS: 285-654-7
• Product Categories: Anilines, Amides & Amines;Fluorine Compounds;Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 85118-02-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 161-165 °C(lit.)
• Boiling Point: 200.4±30.0℃ (760 Torr)
• Flash Point: 75.0±24.6℃
• Appearance: WHITE TO BROWN POWDER, CRYSTALS, CRYSTALLINE POWDER AND/OR CHUNKS
• Density: 1.348±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.325mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.19±0.50(Predicted)
• CAS DataBase Reference: 2,4-DIFLUOROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROBENZAMIDE(85118-02-1)
• EPA Substance Registry System: 2,4-DIFLUOROBENZAMIDE(85118-02-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 85118-02-1(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C7H5F2NO/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H2,10,11)

Upstream product

• 1583-58-0 2,4-difluoro-benzoic acid 
• 72482-64-5 2,4-difluorobenzoyl chloride 
• 1550-35-2 2,4-difluorobenzaldehyde 

Downstream Products

• 175276-92-3 2,4-difluorobenzene-1-carbothioamide 
• 104326-92-3 ethyl o,p-difluorobenzimidate 
• 3939-09-1 2,4-difluorobenzonitrile 
• 67152-20-9 2,4-difluoro-5-nitrobenzonitrile 
• 952285-54-0 5-amino-2,4-difluorobenzonitrile 
• 17654-70-5 4,6-difluoro-isophthalonitrile 
• 262589-15-1 2-(2,4-difluorophenyl)thiazole-4-carboxylic acid 
• 175276-93-4 ethyl 2-(2,4-difluorophenyl)thiazole-4-carboxylate 
• 881401-84-9 [2-(2,4-Difluoro-phenyl)-thiazol-4-yl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Novel method for synthesizing dolutegravir key intermediate 2,4-difluorobenzylamine

The invention discloses a novel production method which is concise and green in route, low in cost and easy to industrialize to prepare 2,4-difluorobenzylamine. The method comprises the following twosteps: a) at certain pressure, carrying out a carbonylation reaction on m-difluorobenzene and CO in the presence of a catalyst so as to generate 2,4-difluorobenzaldehyde, or carrying out a formylationreaction on m-difluorobenzene, namely carrying out chlorocarbene substitution on m-difluorobenzene in a chloroform strong base system, and further carrying out hydrolysis so as to prepare a product 2,4-difluorobenzaldehyde (Reimer-Tiemann reactions); b) putting the product 2,4-difluorobenzaldehyde of the step a) into an alcohol solvent, at certain pressure, in the presence of the catalyst, carrying out a reduction ammonolysis reaction on the component with an ammonia gas and hydrogen directly in the presence of a catalyst, or enabling the component to react with ammonium formate, thereby obtaining the 2,4-difluorobenzylamine. The preparation method disclosed by the invention is simple and easy in raw material obtaining, concise in route, green and environmentally friendly, low in cost andeasy in industrial production.

A 4, 6 - double-halogenated isophthalonitrile preparation method (by machine translation)

The present invention relates to the technical field of the synthesis of pharmaceutical intermediates, in particular to a 4, 6 - double-halogenated isophthalonitrile preparation method, through the use of cheap and easily obtained 2, 4 - double-halo benzoic acid as the raw material, the reaction of the halide, the amidation reaction, dehydration reaction, the nitration reaction, reduction reaction, the diazotization reaction, the substitution reaction for the synthesis of 4, 6 - double-halogenated isophthalonitrile; the total yield can be 21.5%. The process route is easily obtained and cheap materials, few by-products, the purification treatment is the process is simple, easy to realize industrial production. (by machine translation)