851679-73-7Relevant articles and documents
Chiral bis(amino alcohol)oxalamides as ligands for asymmetric catalysis. Ti(IV) catalyzed enantioselective addition of diethylzinc to aldehydes
Blay, Gonzalo,Fernandez, Isabel,Marco-Aleixandre, Alicia,Pedro, Jose R.
, p. 1207 - 1213 (2005)
Several chiral bis(aminoalcohol)oxalamides with C2-symmetry have been prepared and used as ligands for the enantioselective addition of diethylzinc to aromatic and aliphatic aldehydes. The reaction proceeds in the presence of titanium isopropoxide to give the corresponding (S)-alcohols with ee up to 78%. In the absence of Ti(IV), the alcohols with the opposite configuration are obtained.