852616-64-9

Basic information

• Product Name: tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate
• Synonyms: tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate
• CAS NO: 852616-64-9
• Molecular Weight: 437.654
• Mol File: 852616-64-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate(852616-64-9)
• EPA Substance Registry System: tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate(852616-64-9)

Safety Data

• Hazardous Substances Data: 852616-64-9(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 205444-34-4 (S)-tert-butyl 2-(hydroxymethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 34619-03-9 tert-butyldicarbonate 
• 51372-93-1 (S)-tert-butyl (1-hydroxy-4-(methylthio)butan-2-yl)carbamate 
• 51-35-4 4R-4-hydroxyproline 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 74844-93-2 N-BOC-3,4-didehydro-(S)-proline methyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 920009-47-8 (2S,3S)-3-(N-allyl-N-tert-butoxycarbonyl)amino-4-pentene-1,2-diol 
• 920009-51-4 (2S)-N-tert-butoxycarbonyl-2-[(1S)-1,2-dihydroxyethyl]-2,5-dihydropyrrole 

Downstream Products

• 1352786-24-3 (2R,3S,4S)-tert-butyl 2-[(tert-butyldiphenylsilyloxy)methyl]-4-(ethoxycarbonylamino)-3-hydroxypyrrolidine-1-carboxylate 
• 1352786-25-4 (2S,3R,4S)-tert-butyl 2-[(tert-butyldiphenylsilyloxy)methyl]-3-(ethoxycarbonylamino)-4-hydroxypyrrolidine-1-carboxylate 
• 1352786-26-5 (2R,3S,4S)-tert-butyl 4-(benzyloxycarbonylamino)-2-[(tert-butyldiphenylsilyloxy)methyl]-3-hydroxypyrrolidine-1-carboxylate 
• 1352786-27-6 (2S,3R,4S)-tert-butyl 3-(benzyloxycarbonylamino)-2-[(tert-butyldiphenylsilyloxy)methyl]-4-hydroxypyrrolidine-1-carboxylate 
• 852616-73-0 (2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 
• 852616-75-2 (2S,3R,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 
• 852616-74-1 (2S,3S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 
• 852616-69-4 (2R,3R,4S)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-hydroxy-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 

Relevant articles and documents

Design, synthesis and biological evaluation of isoxazole-based CK1 inhibitors modified with chiral pyrrolidine scaffolds

In this study, we report on the modification of a 3,4-diaryl-isoxazole-based CK1 inhibitor with chiral pyrrolidine scaffolds to develop potent and selective CK1 inhibitors. The pharmacophore of the lead structure was extended towards the ribose pocket of

Synthesis of 3′-deoxy-3′-difluoromethyl azanucleosides from trans-4-hydroxy-L-proline

Two strategies were tried to synthesize 3′-deoxy-3′- difluoromethyl azanucleosides. After the failure of the first route, the key intermediate 12 from trans-4-hydroxyproline 7 in 8 steps was stereoselectively prepared. The alcohol 12 was subjected to sele