852853-10-2Relevant articles and documents
N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase
Di Gioia, M. Luisa,Leggio, Antonella,Liguori, Angelo
, p. 3892 - 3897 (2007/10/03)
An efficient and general solution-phase method for the site-specific N-methylation of peptides has been developed. This novel procedure involves synthesis of N-nosyl protected peptides and their subsequent N-methylation with diazomethane. Its efficiency w