85302-08-5

Basic information

• Product Name: 2-[(dimethylamino)methylidene]-5-phenylcyclohexane-1,3-dione
• Synonyms: 2-[(dimethylamino)methylidene]-5-phenylcyclohexane-1,3-dione;2-((dimethylamino)methylene)-5-phenylcyclohexane-1,3-dione
• CAS NO: 85302-08-5
• Molecular Formula: C₁₅H₁₇NO₂
• Molecular Weight: 243.30098
• EINECS: -0
• Mol File: 85302-08-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(dimethylamino)methylidene]-5-phenylcyclohexane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(dimethylamino)methylidene]-5-phenylcyclohexane-1,3-dione(85302-08-5)
• EPA Substance Registry System: 2-[(dimethylamino)methylidene]-5-phenylcyclohexane-1,3-dione(85302-08-5)

Safety Data

• Hazardous Substances Data: 85302-08-5(Hazardous Substances Data)

Upstream product

• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 

Downstream Products

• 87379-59-7 3-Hydroxy-2-iminomethyl-5-phenyl-cyclohex-2-enone 
• 87379-54-2 2-amino-7-phenyl-7,8-dihydro-5-(6H)-quinazolinone 
• 64500-73-8 2,5-dioxo-7-phenyl-1,2,5,6,7,8-hexahydro-quinoline-3-carbonitrile 
• 84548-16-3 5,6,7,8-Tetrahydro-7-phenyl-2,5-dioxo-2H-1-benzopyran-3-carboxamide 
• 87379-53-1 2-Methyl-7-phenyl-7,8-dihydro-6H-quinazolin-5-one 
• 87287-43-2 6-Phenyl-6,7-dihydro-5H-benzo[d]isoxazol-4-one 
• 29974-41-2 2.7-Diphenyl-5-oxo-5.6.7.8-tetrahydrochinazolin 
• 50839-31-1 1,6-diphenyl-1,5,6,7-tetrahydro-indazol-4-one 
• 85302-18-7 1-Methyl-6-phenyl-1,5,6,7-tetrahydro-indazol-4-one 
• 106551-73-9 7-Phenyl-1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarboxamide 
• 155857-93-5 2-[(3-Hydroxy-propylamino)-methylene]-5-phenyl-cyclohexane-1,3-dione 
• 106551-83-1 7-Phenyl-7,8-dihydro-2,5-(1H,6H)-quinolinedione 
• 106551-78-4 7-Phenyl-1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarboxylic acid 
• 41732-12-1 2-Hydroxy-6-oxo-4-phenyl-cyclohex-1-enecarbonitrile 

Relevant articles and documents

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention of autophagy. Post-translational modifications like acetylation of Lys49 on the LIR-interacting surface could disrupt the interaction, offering an opportunity to design covalent small molecules interfering with the interface. Through screening covalent compounds, we discovered a small molecule modulator of LC3A/B that covalently modifies LC3A/B protein at Lys49. Activity-based protein profiling (ABPP) based evaluations reveal that a derivative molecule DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells. DC-LC3in-D5 compromises LC3B lipidation in vitro and in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation. DC-LC3in-D5 could serve as a powerful tool for autophagy research as well as for therapeutic interventions.

Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies

A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. Of not

USE OF AMINOMETHYLENECYCLOHEXANE-1,3-DIONE COMPOUND

The present invention relates to use of an aminomethylenecyclohexane-1,3-dione compound, more particularly to use of a compound shown in the following formula (I) or a pharmaceutically acceptable salt thereof alone or in combination with other drug in pre