853056-96-9Relevant articles and documents
Structure and conserved function of iso-branched sphingoid bases from the nematode: Caenorhabditis elegans
Thomas Hannich,Mellal, Denia,Feng, Suihan,Zumbuehl, Andreas,Riezman, Howard
, p. 3676 - 3686 (2017/07/10)
Sphingolipids are bio-active metabolites that show structural diversity among eukaryotes. They are essential for growth of all eukaryotic cells but when produced in an uncontrolled manner can lead to cell death and pathologies including auto-immune reacti
Asymmetric synthesis of 1-deoxyazasugars from chiral aziridines
Singh, Alok,Kim, Bongchan,Lee, Won Koo,Ha, Hyun-Joon
experimental part, p. 1372 - 1380 (2011/04/16)
A general and facile synthesis of enantiopure 1-deoxyazasugars was achieved from stereoselective dihydroxylation of a common synthetic intermediate, piperidine ring fused oxazolidin-2-one, originating from a commercially available starting substrate, chiral aziridine-2-carboxylate, in high yields. The Royal Society of Chemistry 2011.
SPHINGOLIPID DERIVATIVES AND THE COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME
-
Page/Page column 11; 12; 15; 16; 18; 20; 22, (2010/02/15)
Disclosed are a novel sphingolipid derivative having a sphingosine kinase suppressing activity and a composition containing the same. When the newly synthesized sphingolipid derivative of the invention is used, it is possible to maintain concentrations of ceramide and sphingosine to be high by preventing ceramide and sphingosine from being phosphorylated due to sphingosine kinase since an activity of sphingosine kinase is suppressed. In addition, since the apoptosis is induced in a cancer cell by ceramide and sphingosine, it is possible to treat or prevent a cancer or disease related to the cancer. Further, it is possible to treat or prevent a hyper- proliferative disease such as cancer or proliferation-promoting activity of sphingosine kinase. Accordingly, the composition containing the same can be used as a composition for suppressing sphingosine kinase and a composition for treating or preventing a cancer or hyper-proliferative disease.