854010-13-2Relevant articles and documents
Related substance of pyrazole compound, and preparation method and application of related substance
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Paragraph 0055; 0056, (2018/01/03)
The invention discloses a related substance of a pyrazole compound, and a preparation method and application of the related substance. The related substance is shown as the formula A. The preparation method of the related substance A comprises the followi
Detection and Treatment of Schizophrenia
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, (2011/02/25)
The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.