854139-74-5Relevant articles and documents
Synthesis and evaluation of 3-(carboxymethylidene)- and 3-(carboxymethyl)penicillinates as inhibitors of β-lactamase
Buynak, John D.,Ghadachanda, Venkat Rao,Vogeti, Lakshminaryana,Zhang, Hongming,Chen, Hansong
, p. 4510 - 4513 (2007/10/03)
Penicillin-resistant bacteria can often be treated through the co-administration of an antibiotic and a β-lactamase inhibitor. Current inhibitors target only class Aβ-lactamases. We report two new series of C3-modified penicillin sulfones, having either a simple methylene group (i.e., a homologue) or exocyclic unsaturation between the thiazolidine ring and the C3 carboxylate. The homologue has 10-fold better activity against a class C β-lactamase than does sulbactam itself. By contrast, the exocyclic C3 unsaturated compounds are less active.