854371-73-6Relevant articles and documents
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
Hu, Yonghan,Xiang, Jason S.,DiGrandi, Martin J.,Du, Xuemei,Ipek, Manus,Laakso, Leif M.,Li, Jianchang,Li, Wei,Rush, Thomas S.,Schmid, Jean,Skotnicki, Jerauld S.,Tam, Steve,Thomason, Jennifer R.,Wang, Qin,Levin, Jeremy I.
, p. 6629 - 6644 (2005)
Modification of α-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL.