85450-51-7

Basic information

• Product Name: 3-Benzylcyclohexanone
• Synonyms: 3-Benzylcyclohexanone
• CAS NO: 85450-51-7
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.26554
• Mol File: 85450-51-7.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Benzylcyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzylcyclohexanone(85450-51-7)
• EPA Substance Registry System: 3-Benzylcyclohexanone(85450-51-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 85450-51-7(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 770-09-2 benzyltrimethylsilane 
• 5925-78-0 benzyl methyl selenide 
• 75155-28-1 1-phenyl-1-(methylseleno)ethane 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 6921-34-2 benzylmagnesium chloride 
• 52457-04-2 1-benzylcyclohexa-2,5-dienyl-1-carboxylic acid 
• 62673-31-8 benzyl(bromo)zinc 
• 598-30-1 sec.-butyllithium 
• 100-52-7 benzaldehyde 
• 5281-18-5 benzaldehyde, hydrazone 
• 1939-99-7 benzenesulfonyl chloride 
• 1599438-21-7 1-(1-phenylprop-2-en-2-yl)cyclobutanol 

Downstream Products

• 125443-18-7 ethyl 2-<3-benzylcyclohex-1-enyl>propionate 
• 22071-15-4 ketoprofen 
• 60658-04-0 ethyl 2-<3-benzoylphenyl>propionate 
• 86618-02-2 ethyl 2-<3-benzylphenyl>propionate 
• 113361-04-9 5-benzyl-1-methylcyclohexene 

Relevant articles and documents

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions

The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, we report an "ene"-reductase catalyzed asymmetric hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Four rounds of site saturation mutagenesis were used to access a variant of the "ene"-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles capable of catalyzing a cyclization to furnish β-chiral cyclopentanones with high levels of enantioselectivity. Additionally, wild-type NCR can catalyze intermolecular couplings with precise stereochemical control over the radical termination step. This report highlights the utility for ground-state electron transfers to enable non-natural biocatalytic C-C bond forming reactions.

Electrochemical Radical Selenylation/1,2-Carbon Migration and Dowd-Beckwith-Type Ring-Expansion Sequences of Alkenylcyclobutanols

Electrochemical oxidative radical selenylation/1,2-carbon migration and Dowd-Beckwith-type ring-expansion sequences of alkenylcyclobutanols were developed in this study. This approach is environmentally benign and uses shelf-stable diselenides as selenium

Isoquinolone compound and application thereof

The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.