854601-80-2 Usage
Description
m-PEG5-bromide is a PEG (polyethylene glycol) linker that incorporates a bromide group, which serves as an excellent leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer enhances solubility in aqueous environments, making it a versatile component in various applications.
Uses
Used in Bioconjugation:
m-PEG5-bromide is used as a bioconjugation agent for attaching biologically active molecules to other entities. The bromide group facilitates the coupling process through nucleophilic substitution, while the PEG spacer improves solubility and stability of the resulting conjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, m-PEG5-bromide is used as a component in drug delivery systems to improve the solubility and bioavailability of therapeutic agents. The PEG spacer can help in the formation of nanoparticles or other carriers, enhancing the drug's performance and reducing side effects.
Used in Diagnostic Imaging:
m-PEG5-bromide is utilized in diagnostic imaging as a modifier for contrast agents. The PEG spacer can improve the pharmacokinetics and biodistribution of imaging agents, leading to better imaging outcomes and patient safety.
Used in Material Science:
In material science, m-PEG5-bromide is employed as a functionalizing agent for the synthesis of new materials with tailored properties. The bromide group allows for the attachment of various functional groups, while the PEG spacer can influence the material's hydrophilicity and other characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 854601-80-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,4,6,0 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 854601-80:
(8*8)+(7*5)+(6*4)+(5*6)+(4*0)+(3*1)+(2*8)+(1*0)=172
172 % 10 = 2
So 854601-80-2 is a valid CAS Registry Number.
854601-80-2Relevant articles and documents
Engineering Nanoparticulate Organic Photocatalysts via a Scalable Flash Nanoprecipitation Process for Efficient Hydrogen Production
Guo, Zhiqian,Wu, Yongzhen,Yu, Miaojie,Zhang, Weiwei,Zhu, Weihong
, p. 15590 - 15597 (2021/06/07)
Directly converting sunlight into hydrogen fuels using particulate photocatalysts represents a sustainable route for clean energy supply. Organic semiconductors have emerged as attractive candidates but always suffer from optical and exciton recombination losses with large exciton “dead zone” inside the bulk material, severely limiting the catalytic performance. Herein, we demonstrate a facile strategy that combines a scalable flash nanoprecipitation (FNP) method with hydrophilic soluble polymers (PC-PEG5 and PS-PEG5) to prepare highly efficient nanosized photocatalysts without using surfactants. Significantly, a 70-fold enhancement of hydrogen evolution rate (HER) is achieved for nanosized PC-PEG5, and the FNP-processed PS-PEG5 shows a peak HER rate of up to 37.2 mmol h?1 g?1 under full-spectrum sunlight irradiation, which is among the highest results for polymer photocatalysts. A scaling-up production of nanocatalyst is demonstrated with the continuously operational FNP.
Chemically modified small molecules
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Page/Page column 25-26, (2010/02/12)
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
