857-45-4 Usage
Check Digit Verification of cas no
The CAS Registry Mumber 857-45-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,5 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 857-45:
(5*8)+(4*5)+(3*7)+(2*4)+(1*5)=94
94 % 10 = 4
So 857-45-4 is a valid CAS Registry Number.
InChI:InChI=1/C23H22N2O/c1-17-16-21(24-19-12-6-3-7-13-19)20-14-8-9-15-22(20)25(17)23(26)18-10-4-2-5-11-18/h2-15,17,21,24H,16H2,1H3/t17-,21-/m1/s1
857-45-4Relevant articles and documents
Tetrahydroquinoline derivatives as CRTH2 antagonists
Liu, Jiwen,Wang, Yingcai,Sun, Ying,Marshall, Derek,Miao, Shichang,Tonn, George,Anders, Penny,Tocker, Joel,Tang, H. Lucy,Medina, Julio
scheme or table, p. 6840 - 6844 (2010/05/19)
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 an