857601-15-1

Basic information

• Product Name: (2-chloro-4-methylphenyl)(4-methoxyphenyl)amine
• Synonyms: (2-chloro-4-methylphenyl)(4-methoxyphenyl)amine
• CAS NO: 857601-15-1
• Molecular Weight: 247.724
• Mol File: 857601-15-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-chloro-4-methylphenyl)(4-methoxyphenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-4-methylphenyl)(4-methoxyphenyl)amine(857601-15-1)
• EPA Substance Registry System: (2-chloro-4-methylphenyl)(4-methoxyphenyl)amine(857601-15-1)

Safety Data

• Hazardous Substances Data: 857601-15-1(Hazardous Substances Data)

Upstream product

• 95-75-0 3,4-Dichlorotoluene 
• 104-94-9 4-methoxy-aniline 
• 6640-27-3 2-chloro-p-cresol 

Relevant articles and documents

Palladium C-N bond formation catalysed by air-stable robust polydentate ferrocenylphosphines: A comparative study for the efficient and selective coupling of aniline derivatives to dichloroarene

The arylation of aniline derivatives with dichloroarenes under a low palladium content (below the currently used 5 to 10 mol%) was studied using nine different ferrocenylphosphine ligands, including the easily accessible 1,1′-bis(diphenylphosphino)ferrocene, DPPF. The electron-enriched air-stable tridentate ferrocenylpolyphosphine 1,2-bis(diphenylphosphino)- 1′-(diisopropylphosphino)-4-tert-butylferrocene, L5, employed in 2 mol% in combination with 1 mol% [PdCl(η3-C3H 5)]2 allows an efficient and selective coupling, while such demanding substrates currently induce chloroarene homocoupling and/or dehalogenation processes. The scope and limitation of the optimized system are explored, with a focus on electron-poor fluoroanilines (deactivated nucleophiles) and electron-rich methylated and methoxylated dichlorobenzenes (deactivated electrophiles). The Royal Society of Chemistry 2014.