85787-95-7

Basic information

• Product Name: 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE
• Synonyms: 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE;2-Amino-8H-indeno[1,2-d][1,3]thiazole;8H-Indeno[1,2-d]thiazol-2-amine
• CAS NO: 85787-95-7
• Molecular Formula: C₁₀H₈N₂S
• Molecular Weight: 188.24892
• Mol File: 85787-95-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 268-270
• Boiling Point: 399.6 °C at 760 mmHg
• Flash Point: 195.5 °C
• Appearance: /
• Density: 1.412 g/cm³
• Vapor Pressure: 1.35E-06mmHg at 25°C
• Refractive Index: 1.753
• PKA: 4.69±0.20(Predicted)
• CAS DataBase Reference: 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE(85787-95-7)
• EPA Substance Registry System: 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE(85787-95-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 85787-95-7(Hazardous Substances Data)

Usage

General Description

The chemical 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE, also known as 2-amino-8H-indeno[1,2-d][1,3]thiazole, is a heterocyclic compound with a fused 6-membered ring system containing nitrogen and sulfur atoms. It is a yellow to beige powder that is sparingly soluble in water and organic solvents. 8H-INDENO[1,2-D][1,3]THIAZOL-2-AMINE has potential applications in pharmaceutical and agrochemical industries, as it possesses interesting biological activities and may serve as a starting material for the synthesis of various derivatives with diverse properties. Its chemical structure and properties make it a valuable building block in organic synthesis for the development of new materials and compounds in drug discovery and other fields.

InChI:InChI=1/C10H8N2S/c11-10-12-9-7-4-2-1-3-6(7)5-8(9)13-10/h1-4H,5H2,(H2,11,12)

Upstream product

• 83-33-0 inden-1-one 
• 17356-08-0 thiourea 
• 1775-27-5 2-bromoindanone 
• 1579-14-2 2-chloroindanone 
• 95-13-6 1-indene 

Relevant articles and documents

Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH)

An efficient procedure for the synthesis of 2-aminothiazoles via DBH-mediated oxidative cyclization of styrenes and thioureas is reported. Various alkenes were successfully transformed to the corresponding 2-aminothiazoles in yields of 10–81% via a two-step one-pot manner using DBH as both the bromine source and oxidant. The method can be readily carried out in gram-scale and successfully applied to the synthesis of anti-inflammatory drug fanetizole using styrene as starting material.

Mechanochemical solid-state synthesis of 2-aminothiazoles, quinoxalines and benzoylbenzofurans from ketones by one-pot sequential acid- and base-mediated reactions

α-Chloroketones-obtained by the atom-economical chlorination of ketones with trichloroisocyanuric acid (TCCA) in the presence of p-TSA under ball-milling conditions-were set up for a sequential base-mediated condensation reaction with thiourea/thiosemicarbazides, o-phenylenediamine and salicylaldehyde to afford 2-aminothiazoles, 2-hydrazinylthiazoles, quinoxalines and benzoylbenzofurans, respectively, in respectable yields. The viability of one-pot sequential acid- and base-mediated reactions in the solid state under ball-milling conditions is thus demonstrated.

SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+-ACTIVATED K+ CHANNEL KCA3.1 AND THEIR METHODS OF USE

Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.