860205-92-1

Basic information

• Product Name: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid
• Synonyms: 3-Quinolinecarboxylicacid,7-bromo-4-hydroxy-(5CI);7-bromo-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;7-Bromo-4-hydroxy-3-quinolinecarboxylic acid;4-Hydroxy-7-broMoquinoline-3-caroboxylic acid;7-bromo-4-oxo-1H-quinoline-3-carboxylic acid
• CAS NO: 860205-92-1
• Molecular Formula: C10H6BrNO3
• Molecular Weight: 268.06
• EINECS: -0
• Product Categories: QUINOLINE
• Mol File: 860205-92-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 408.023 °C at 760 mmHg
• Flash Point: 200.565 °C
• Appearance: /
• Density: 1.862
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.65±0.30(Predicted)
• CAS DataBase Reference: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid(860205-92-1)
• EPA Substance Registry System: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid(860205-92-1)

Safety Data

• Hazardous Substances Data: 860205-92-1(Hazardous Substances Data)

Usage

General Description

7-Bromo-4-hydroxy-3-quinolinecarboxylic acid is a chemical compound with the molecular formula C10H6BrNO3. It is a derivative of quinolinecarboxylic acid and contains a bromine atom and a hydroxyl group attached to the quinoline ring. 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid has potential application in pharmaceutical research and drug development due to its structural features and biological activities. It may be used as a building block in the synthesis of new drug candidates and could potentially exhibit antibacterial, antiviral, or anticancer properties. Further research and testing are needed to fully understand the potential uses and effects of 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid.

Upstream product

• 208580-23-8 ethyl 7-bromo-4-hydroxyquinoline-3-carboxylate 
• 351893-47-5 ethyl α-carbethoxy-β-m-bromoanilinoacrylate 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 82121-06-0 4-hydroxy-7-bromoquinoline 
• 1445786-66-2 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid 
• 1445789-26-3 methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate 
• 1445789-92-3 methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate 
• 1445786-95-7 4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-(quanidinomethyl)quinoline-3-carboxamide 
• 1445786-26-4 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylamino)benzoic acid 
• 1445790-05-5 7-cyano-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide 
• 1445790-07-7 C₂₃H₂₂BrF₃N₄O₃S 
• 1445790-09-9 7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide 
• 1445787-00-7 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-(dimethylcarbamoyl)phenyl)amino)quinoline-3-carboxamide 
• 1445786-28-6 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(propylamino)benzoic acid 
• 1445787-11-0 4-((3-cyclopentyl-5-(hydroxymethyl)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide 
• 1445787-15-4 methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate 
• 1445787-17-6 4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide 

Relevant articles and documents

Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines

Aminoquinolines (AQs) with diaminoalkane side chains (-HNRNEt2) shorter or longer than the isopentyl side chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -resistant Plasmodium falciparum. (De, D.; et al. Am. J. Trop. Med. Hyg. 1996, 55, 579-583). In the studies reported here, we examined structure-activity relationships (SARs) among AQs with different N,N-diethyldiaminoalkane side chains and different substituents at the 7-position occupied by Cl in chloroquine. 7-Iodo- and 7- bromo-AQs with diaminoalkane side chains [-HN(CH2)2NEt2, -HN(CH2)3NEt2, or -HNCHMeCH2NEt2] were as active as the corresponding 7-chloro-AQs against both chloroquine-susceptible and -resistant P. falciparum (IC50s of 3-12 nM). In contrast, with one exception, 7-fluoro-AQs and 7-trifluoromethyl-AQs were less active against chloroquine-susceptible P. falciparum (IC50s of 15-50 nM) and substantially less active against chloroquine-resistant P. falciparum (IC50s of 18-500 nM). Furthermore, most 7-OMe-AQs were inactive against both chloroquine-susceptible (IC50s of 17-150 nM) and -resistant P. falciparum (IC50s of 90-3000 nM).