86048-40-0

Basic information

• Product Name: Quazolast
• Synonyms: Quazolast;5-Chlorooxazolo[4,5-h]quinoline-2-carboxylic acid methyl ester;methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate
• CAS NO: 86048-40-0
• Molecular Formula: C12H7 Cl N2 O3
• Molecular Weight: 262.65
• Mol File: 86048-40-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 425.7°C at 760 mmHg
• Flash Point: 211.3°C
• Appearance: /
• Density: 1.485g/cm³
• Vapor Pressure: 1.87E-07mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: Quazolast(CAS DataBase Reference)
• NIST Chemistry Reference: Quazolast(86048-40-0)
• EPA Substance Registry System: Quazolast(86048-40-0)

Safety Data

• Hazardous Substances Data: 86048-40-0(Hazardous Substances Data)

Usage

Uses

Anti-asthmatic; inhibitor (mediator release).

InChI:InChI=1/C12H7ClN2O3/c1-17-12(16)11-15-8-5-7(13)6-3-2-4-14-9(6)10(8)18-11/h2-5H,1H3

Upstream product

• 18370-95-1 methyl 2,2,2-trimethoxyacetate 
• 18471-93-7 7-amino-5-chloro-8-hydroxyquinoline 
• 18472-03-2 5-chloro-7-nitro-8-hydroxy-quinoline 
• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 88362-74-7 2-cyano-5-chloro-1,3-oxazolo-[4,5-h]quinoline 

Relevant articles and documents

Method of prevention and treatment of peptic ulcers

Disclosed is a method for prophylactic and therapeutic treatment of peptic ulcers which comprises the administration of a pharmaceutical composition containing a compound of the formula STR1 or a pharmaceutically acceptable salt thereon, wherein R1 and R2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R3 N wherein R3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminolakyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formuloximino, tetrazolyl, carbalkoxyalky or caboxyalkyl, and m is 0 or 1, in admixture or in association with a pharmaceutically acceptable carrier.

Synthesis and Antiallergic Activities of 1,3-Oxazoloquinolines

A series of new 1,3-oxazoloquinolines has been prepared.These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated passive cutaneous anaphy

A SIMPLE ONE-STEP SYNTHESIS OF ALKYL BENZAZOL-2-CARBOXYLATES

A simple one-step synthesis of alkyl benzazol-2-carboxylates employing alkyl trialkoxyacetate is described.