861840-21-3Relevant articles and documents
Facile synthesis of the glucosylceramide synthase inhibitor GZ667161
Hewlett, Elizabeth D.,Melenski, Edward,Qiu, Frederick V.,Leung, Hiu T.,Jacobson, Marlene,Qiu, Feng,Abou-Gharbia, Magid,Childers, Wayne
, (2020/09/10)
GZ667161 (GZ-161) is a quinuclidine-based small molecule inhibitor of the lysosomal enzyme glucosylceramide synthase. It represents an important tool molecule for studying the contribution of glycosphingolipids to disease pathology in lysosomal storage di
Glucosylceramide synthase inhibitors
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, (2015/09/28)
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.