861841-94-3 Usage
Description
1-(5-(Benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its benzyloxy, hydroxy, and nitro functional groups attached to a phenyl ring, which contribute to its reactivity and potential applications in chemical reactions and drug development.
Uses
Used in Pharmaceutical Industry:
1-(5-(Benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone is used as a key intermediate in the synthesis of Olodaterol (O262000), a novel inhaled β2-adrenoceptor agonist. 1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone exhibits a 24-hour bronchodilatory efficacy, making it a valuable component in the development of long-acting asthma and chronic obstructive pulmonary disease (COPD) treatments.
As an intermediate, 1-(5-(Benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone plays a crucial role in the production of Olodaterol, which is designed to provide sustained relief for respiratory conditions. Its unique structure allows for the formation of the final drug product through a series of chemical reactions, ultimately leading to a medication that can improve the quality of life for patients suffering from respiratory ailments.
Check Digit Verification of cas no
The CAS Registry Mumber 861841-94-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,1,8,4 and 1 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 861841-94:
(8*8)+(7*6)+(6*1)+(5*8)+(4*4)+(3*1)+(2*9)+(1*4)=193
193 % 10 = 3
So 861841-94-3 is a valid CAS Registry Number.
InChI:InChI=1S/C15H13NO5/c1-10(17)13-7-12(8-14(15(13)18)16(19)20)21-9-11-5-3-2-4-6-11/h2-8,18H,9H2,1H3
861841-94-3Relevant articles and documents
CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE
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, (2019/11/11)
The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.
PROCESS FOR THE MANUFACTURING OF BETA MIMETICS
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Page/Page column 6, (2010/02/17)
The invention relates to a method for producing betamimetics of formula (1), wherein in which n represents 1 or 2; R1 represents hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 represents hydrogen, halogen, C
PROCESS FOR THE MANUFACTURING OF BETAMIMETICS
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Page/Page column 11, (2008/06/13)
The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4/su