861881-24-5

Basic information

• Product Name: N¹-(3-(dimethylamino)propyl)-N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine
• Synonyms: N¹-(3-(dimethylamino)propyl)-N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine
• CAS NO: 861881-24-5
• Molecular Weight: 275.317
• Mol File: 861881-24-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 340.1±42.0 °C(Predicted)
• Density: 1.164±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N¹-(3-(dimethylamino)propyl)-N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-(3-(dimethylamino)propyl)-N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine(861881-24-5)
• EPA Substance Registry System: N¹-(3-(dimethylamino)propyl)-N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine(861881-24-5)

Safety Data

• Hazardous Substances Data: 861881-24-5(Hazardous Substances Data)

Upstream product

• 4543-96-8 N,N,N'-trimethylpropane-1,3-diamine 
• 926277-94-3 N-(3-(dimethylamino)propyl)-N-methyl-2-nitro-4-(trifluoromethyl)benzenamine 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 110-95-2 N,N,N'N'-tetramethyl-1,3-propanediamine 

Downstream Products

• 1191932-28-1 2-amino-8-bromo-6-(5-N-{2-[N-(3-dimethylaminopropyl)-N-methylamino]-5-trifluoromethylphenyl}carbamoyl-2-methylphenyl)-7-methoxyquinazoline 
• 1025751-26-1 N-(2-((3-dimethylamino-propyl)(methyl)amino)-5-trifluoromethyl-phenyl)-2-fluoro-5-(3-(oxazol-5-yl)-pyridin-2-yloxy)benzamide 
• 926036-44-4 N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide 

Relevant articles and documents

MULTI-CYCLIC COMPOUNDS AND METHODS OF USE

The present invention relates to compounds of Formulas I and II, wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic inter

Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase

The recognition that aberrant angiogenesis contributes to the pathology of inflammatory diseases, cancer, and myocardial ischemia has generated considerable interest in the molecular mechanisms that regulate blood vessel growth. The receptor tyrosine kinase Tie-2 is expressed primarily by vascular endothelial cells and is critical for embryonic vasculogenesis. Interference with the Tie-2 pathway by diverse blocking agents such as soluble Tie-2 receptors, anti-Tie-2 intrabodies, anti-Ang-2 antibodies, and peptide-F c conjugates has been shown to suppress tumor growth in xenograft studies. An alternative strategy for interfering with the Tie-2 signaling pathway involves direct inhibition of the kinase functions of the Tie-2 receptor. Herein we describe the development of alkynylpyrimidine amide derivatives as potent, selective, and orally available ATP-competitive inhibitors of Tie-2 autophosphorylation.

PROTEIN KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.