862189-95-5

Basic information

• Product Name: MIRODENAFIL
• Synonyms: MIRODENAFIL;5-Ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one;4H-Pyrrolo[3,2-d]pyriMidin-4-one,5-ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-;Mirodenafil, >=98%;5-Ethyl-2-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl}-2-propoxyphenyl)-7-propyl-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
• CAS NO: 862189-95-5
• Molecular Formula: C26H37N5O5S
• Molecular Weight: 531.674
• EINECS: 1533716-785-6
• Mol File: 862189-95-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 730.447 °C at 760 mmHg
• Flash Point: 395.56 °C
• Appearance: /
• Density: 1.33
• PKA: 14.96±0.10(Predicted)
• CAS DataBase Reference: MIRODENAFIL(CAS DataBase Reference)
• NIST Chemistry Reference: MIRODENAFIL(862189-95-5)
• EPA Substance Registry System: MIRODENAFIL(862189-95-5)

Safety Data

• Hazardous Substances Data: 862189-95-5(Hazardous Substances Data)

Usage

Description

Mirodenafil, also known as Mvix, is a second-generation phosphodiesterase type 5 inhibitor (PDE5i) that was launched in Korea in November 2007. It is available in tablet formulation or orally dissolving film of 50 and 100 mg. Mirodenafil has been approved only in Korea and has a Tmax of 1.25 hours, T1/2 of 2.5 hours, and an IC50 for PDE5 of 0.34 nmol/L, indicating a relatively high affinity (potency) for PDE5. While its pharmacokinetic profile is similar to that of sildenafil, mirodenafil is 10 times more selective for PDE5 than sildenafil.

Uses

Used in Pharmaceutical Industry:
Mirodenafil is used as a PDE5 inhibitor for the treatment of erectile dysfunction. Its high affinity and selectivity for PDE5 make it an effective treatment option for patients with erectile dysfunction.
Used in Research and Development:
Mirodenafil is also used in research and development for the study of PDE5 and its role in various physiological processes. Its high potency and selectivity for PDE5 make it a valuable tool for investigating the mechanisms of action and potential therapeutic applications of PDE5 inhibitors.

Biological Activity

Mirodenafil (SK3530) is an orally active, highly potent and selective phosphodiesterase-5 (PDE5) inhibitor (IC50 = 338 pM). with therapeutic efficacy in various ED models in vivo. Comparing to sildenafil, mirodenafil shows ~10-times higher PDE5 selectivity in vitro and remains longer in the plasma and corpus cavernosum following oral dosing at 40 mg/kg in rats in vivo.