862543-12-2Relevant articles and documents
A solid-phase approach to novel purine and nucleoside analogs
Chang, Junbiao,Dong, Chunhong,Guo, Xiaohe,Hu, Weidong,Cheng, Senxiang,Wang, Qiang,Chen, Rongfeng
, p. 4760 - 4766 (2007/10/03)
This paper describes a method for the preparation of purine analogs using the solid-phase approach. Nucleoside bases were constructed on Merrifield resin by sequential displacement of purine dichloride with amines, and after detachment, the purine analogs were condensed with d,l-ribofuranoside compounds by the Vorbrueggen method. Thereof, l-ribofuranoside was prepared from l-arabinose via the selective oxidation-reduction procedure of the 2-OH group. Some compounds exhibited moderate activity against HIV-1 in PBM cells.