862686-09-7

Basic information

• Product Name: 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline
• Synonyms: 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline;1-(4-(4-AMino-3-Methylphenyl)piperazin-1-yl)ethanone;1-[4-(4-amino-2-methylphenyl)-1-piperazinyl]Ethanone
• CAS NO: 862686-09-7
• Molecular Formula: C₁₃H₁₉N₃O
• Molecular Weight: 233.32
• Mol File: 862686-09-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 482.3°C at 760 mmHg
• Flash Point: 245.5°C
• Appearance: /
• Density: 1.151g/cm³
• Vapor Pressure: 1.85E-09mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline(862686-09-7)
• EPA Substance Registry System: 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline(862686-09-7)

Safety Data

• Hazardous Substances Data: 862686-09-7(Hazardous Substances Data)

Usage

General Description

4-(4-Acetyl-piperazin-1-yl)-2-methylaniline, also known as APMA, is a chemical compound that is commonly used as a precursor in the synthesis of pharmaceuticals. It is a piperazine derivative with an acetyl and methyl group attached to the piperazine ring, and an aniline group attached to the carbon. APMA is known to have potential biological activities and is being studied for its pharmacological properties, including as a potential anti-cancer agent. It is important to handle APMA with care as it is a potentially hazardous chemical that can cause skin and eye irritation, and may be harmful if ingested or inhaled.

InChI:InChI=1/C13H19N3O/c1-10-9-12(3-4-13(10)14)16-7-5-15(6-8-16)11(2)17/h3-4,9H,5-8,14H2,1-2H3

Upstream product

• 862685-95-8 1-acetyl-4-(2-methyl-4-nitrophenyl)piperazine 
• 455-88-9 5-nitro-2-fluorotoluene 
• 13889-98-0 N-acetylpiperidine 

Relevant articles and documents

Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M

The covalent binding nature of irreversible kinase inhibitors potentially increases the severity of “off-target” toxicity. Based on our continual strategy of chemically tuning the Michael addition acceptors, herein, we further explore the relationship amo

OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS

Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R2