863127-76-8 Usage
Description
(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is a chemical compound with a unique molecular structure that features a chloro-methylphenyl group attached to an ethoxyacrylamide moiety. (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is characterized by its (E)-configuration, which refers to the arrangement of atoms around the double bond in the molecule.
Uses
Used in Pharmaceutical Industry:
(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is used as a reagent for the preparation of potent and selective anti-tumor drugs, such as Dasatinib. It plays a crucial role in the synthesis of these drugs, contributing to their effectiveness in treating various types of cancer.
Dasatinib, a tyrosine kinase inhibitor, is known for its ability to target multiple oncogenic pathways, making it a valuable treatment option for patients with chronic myeloid leukemia and other malignancies. The use of (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide in the production of Dasatinib highlights its importance in the development of life-saving medications.
Check Digit Verification of cas no
The CAS Registry Mumber 863127-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,3,1,2 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 863127-76:
(8*8)+(7*6)+(6*3)+(5*1)+(4*2)+(3*7)+(2*7)+(1*6)=178
178 % 10 = 8
So 863127-76-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H14ClNO2/c1-3-16-8-7-11(15)14-12-9(2)5-4-6-10(12)13/h4-8H,3H2,1-2H3,(H,14,15)/b8-7+
863127-76-8Relevant articles and documents
CRYSTALLINE FORMS OF N-(2-CHLORO-6-METHY]PHENVN-2-[F6-[4-(2-HVDROXVETHVL)-L- PIPERAZINVIL-2-METHVL-4-PVRIMIDINVLLAMINOL-5-THIAZOLECARBOXAMIDE AND THEIR PROCESS THEREOF
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Page/Page column 17; 18, (2017/01/26)
The present invention relates to crystalline 1,2-Propanediol solvate of N-(2-chloro-6- methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-l-piperazinyl]-2-methyl-4-pyrimidinyl]ainino]-5- thiazolecarboxamide compound of formula- lb, its process for the preparation and its use in the preparation of anhydrous crystalline form (N-6) and monohydrate of N-(2-chloro-6- methy lphenyl)-2- [ [6- [4-(2 -hydroxy ethyl)- 1 -piperazinyl] -2-methyl-4-pyrimidinyl]amino] -5 - thiazolecarboxamide. [formula] 1,2-Propanediol solvate Formula- lb
TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
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, (2010/12/29)
The present invention comprises inter alia compounds as shown in formula (I) or a pharmaceutically acceptable salt thereof.
TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
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Page/Page column 53, (2008/12/06)
The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.