863479-23-6Relevant articles and documents
One-step highly selective borylation/Suzuki cross-coupling of two distinct aryl bromides in pure water
Xu, Shan Dong,Sun, Fang Zhou,Deng, Wei Hang,Hao, Han,Duan, Xin Hong
, p. 16464 - 16468 (2018)
A Na2PdCl4-catalysed B2(OH)4-mediated direct cross-coupling of two distinct aryl bromides in pure water is described. This one-step borylation/Suzuki method exhibits an outstanding cross-coupling selectivity and no tendency to produce homocoupling products, therefore leading to biaryls and heterobiaryls in moderate to good yields. Moreover, the reaction has high regio-selectivity and can be scaled-up. Using such a simple, economical and practical protocol, the unsymmetrical diarylation of 3,5-dibromopryidine is achieved.