863668-07-9

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 2-(4-FLUOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID
• CAS NO: 863668-07-9
• Molecular Formula: C₁₀H₆FNO₂S
• Molecular Weight: 223.22
• Mol File: 863668-07-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 412.3 °C at 760 mmHg
• Flash Point: 203.1 °C
• Appearance: /
• Density: 1.447 g/cm³
• Vapor Pressure: 1.55E-07mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID(863668-07-9)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID(863668-07-9)

Safety Data

• Hazardous Substances Data: 863668-07-9(Hazardous Substances Data)

Usage

General Description

2-(4-Fluoro-phenyl)-thiazole-4-carboxylic acid is a chemical compound with the molecular formula C10H6FNO2S. It is a thiazole derivative with a carboxylic acid functional group and a fluorophenyl substituent. 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID is mainly used in the pharmaceutical industry as a building block for the synthesis of new drug candidates. Its structure and properties make it a suitable candidate for potential therapeutic applications. It may also find applications in agricultural and material science due to its unique chemical properties.

InChI:InChI=1/C10H6FNO2S/c11-7-3-1-6(2-4-7)9-12-8(5-15-9)10(13)14/h1-5H,(H,13,14)

Upstream product

• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 
• 1765-93-1 4-fluoroboronic acid 
• 132089-35-1 ethyl 2-(4-fluorophenyl)thiazole-4-carboxylate 

Downstream Products

• 1613022-05-1 C₂₂H₂₀FN₅OS*ClH 
• 1613022-88-0 2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide 
• 1613022-07-3 C₂₁H₁₈FN₅OS*C₂HF₃O₂ 
• 1613022-06-2 2-(4-fluorophenyl)thiazole-4-carboxylic acid (1-pyrrolo[1,2-a]pyrazin-1-yl-pyrrolidin-3-yl)amide 
• 875858-80-3 C₁₀H₆FNOS 
• 1202516-95-7 C₁₂H₁₁FN₂O₂S 

Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).