86386-77-8Relevant articles and documents
Isopropyl amino azole antifungal compound, and preparation method and application thereof
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, (2016/10/10)
The invention relates to the technical field of medicine, and in particular, relates to a new azole alcohol antifungal compound having the following chemical structural general formula defined in the specification, and a preparation method and an application thereof, wherein R is selected from the group consisting of halogen, alkyl, nitro and cyano group. The compound has good antifungal activity on various superficial and deep fungi, has the advantages of high efficiency, low toxicity, wide antifungal spectra and the like compared with current clinical applied antifungal drugs, and can be used for preparation of antifungal drugs.
Allylamine substituted azole antifungal compound and preparation method and application thereof
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, (2016/12/26)
The invention relates to the technical field of medicine, in particular to a novel azole-alcohol antifungal compound with a chemical structural general formula shown in the description and a preparation method and application. The chemical structural general formula is shown in the description, wherein R is selected from alkyl or halogens or nitryl or a cyano group. The compound has good antifungal activity in various superficial fungi and deep fungi. Compared with an existing antifungal drug applied in clinic, the novel azole-alcohol antifungal compound has the advantages of being efficient, low in toxicity, wide in antifungal spectrum and the like and can be used for preparing antifungal drugs.
Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains
Jiang, Zhigan,Gu, Julin,Wang, Chen,Wang, Shengzheng,Liu, Na,Jiang, Yan,Dong, Guoqiang,Wang, Yan,Liu, Yang,Yao, Jianzhong,Miao, Zhenyuan,Zhang, Wannian,Sheng, Chunquan
, p. 490 - 497 (2014/07/07)
Due to increasing incidence of invasive fungal infections and severe drug resistance to triazole antifungal agents, a series of novel antifungal triazoles with substituted triazole-piperidine side chains were designed and synthesized. Most of the target compounds showed good inhibitory activity against a variety of clinically important fungal pathogens. In particular, compounds 8t and 8v were highly active against Candida albicans and Cryptococcus neoformans with MIC values in the range of 0.125 μg/mL to 0.0125 μg/mL. They represent promising leads for the development of new generation of triazole antifungal agents. Molecular docking studies revealed that the target compounds interacted with CACYP51 mainly through hydrophobic and Van der Waals interactions.