86401-95-8 Usage
Description
Methylprednisolone aceponate is a synthetic corticosteroid that exhibits potent anti-inflammatory and immunosuppressive properties. It is a derivative of prednisolone, with an esterified 21-hydroxyl group, which enhances its anti-inflammatory effects and reduces systemic absorption. Methylprednisolone aceponate is used in various medical applications, particularly for the treatment of skin conditions.
Used in Dermatology:
Methylprednisolone aceponate is used as a topical treatment for seborrhoeic dermatitis, an inflammatory skin condition characterized by redness, scaling, and itching. It helps to reduce inflammation and alleviate symptoms by suppressing the immune response and decreasing the production of inflammatory mediators.
Methylprednisolone aceponate is also used as a corticosteroid for the treatment of various skin conditions, including eczema, psoriasis, and contact dermatitis. It works by reducing inflammation, itching, and redness, providing relief to patients suffering from these conditions.
In addition to its use in dermatology, methylprednisolone aceponate may also be used in other medical fields, such as ophthalmology and rheumatology, for the treatment of inflammation and immune-related disorders. However, the primary application of this medication remains in the treatment of skin conditions, where its anti-inflammatory and immunosuppressive properties are most beneficial.
Check Digit Verification of cas no
The CAS Registry Mumber 86401-95-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,0 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 86401-95:
(7*8)+(6*6)+(5*4)+(4*0)+(3*1)+(2*9)+(1*5)=138
138 % 10 = 8
So 86401-95-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1
86401-95-8Relevant articles and documents
6α-Methylprednisolone derivatives
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, (2008/06/13)
A 6α-methylprednisolone derivative of the general formula: STR1 wherein R1 is a hydrogen atom or stands for the grouping STR2 where R3 is a straight or once-branched chain C1-4 alkyl group, a phenyl group or a lower alkoxy- or alkylthio-methyl group, and R2 is a straight or once-branched chain C1-4 alkyl group, a phenyl group or a lower alkoxy- or alkylthio-methyl group, with the proviso that when R2 is ethyl group, R1 should not be a hydrogen atom or R3 should not be ethyl group. This compound exhibits a strong local antiinflammatory effect and is, therefore, useful as a harmless external antiinflammatory drug for various dermal disorders and also as an antiallergic drug for treating asthma and the like allergic diseases.
Studies on topical antiinflammatory corticosteroids. I. Syntheses and vasoconstrictive activities of 11β,17α,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione 17-ester and 17,21-diester derivatives
Sugai,Okazaki,Kajiwara,Kanbara,Naito,Yoshida,Akaboshi,Ikegami,Kamano
, p. 1889 - 1898 (2007/10/02)
Seven 17-ester and thirty-eight 17,21-diester compounds (3 and 4) of 11β,17α,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione (6α-methylprednisolone, 1) were synthesized and thirty-eight selected compounds were tested for vasoconstrictive activity in humans. Except for 4g1 and 4g2, they were more active than the mother compound (1). In particular, the activities of ten compounds (3b-g, 4b9,10, 4c2,3, and 4c6) were equal to or greater than that of 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α-valeryloxy-1,4-pregnadiene-3 ,20-dione (betamethasone 17-valerate, BV). The activities of 21-methoxyacetate compounds (4b9, 4c6 and 4d5) were potent. The structure-activity relationship is discussed.
