864136-41-4

Basic information

• Product Name: 3-(N-BOC-Piperidin-4-yloxy)phenylboronic acid pinacol ester
• Synonyms: 3-(N-BOC-Piperidin-4-yloxy)phenylboronic acid pinacol ester
• CAS NO: 864136-41-4
• Molecular Formula: C22H36BNO6
• Molecular Weight: 421.33534
• Mol File: 864136-41-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(N-BOC-Piperidin-4-yloxy)phenylboronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-BOC-Piperidin-4-yloxy)phenylboronic acid pinacol ester(864136-41-4)
• EPA Substance Registry System: 3-(N-BOC-Piperidin-4-yloxy)phenylboronic acid pinacol ester(864136-41-4)

Safety Data

• Hazardous Substances Data: 864136-41-4(Hazardous Substances Data)

Upstream product

• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 214360-76-6 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 790667-54-8 tert-butyl 4-(3-bromophenoxy)piperidine-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 591-20-8 3-Bromophenol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 

Relevant articles and documents

TREATMENT OF GVHD

The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD ( cGVHD) using compounds having the formulae l-XXV, as set forth herein.

TREATMENT OF OCULAR DISORDERS

The invention provides methods of treatment of ocular disorders, including ocular disease with an angiogenic component. In certain embodiments, the treatment comprises administration of a ROCK2 inhibitor and an angiogenesis inhibitor. In certain embodiments, the ROCK2 inhibitor is ROCK2 selective. In certain embodiments, the angiogenesis inhibitor is a VEGF antagonist, for example, and VEGFR2 antibody.

Inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.